TY - JOUR
T1 - Reserpine withdrawal psychosis
T2 - The possible role of denervation supersensitivity of receptors
AU - Kent, Thomas A.
AU - Wilber, Robert D.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - A case is reported in which abrupt cessation of long term reserpine therapy for hypertension was followed by hallucinations and mania. Reserpine is thought to induce a denervation sensitivity to dopamine in the basal ganglia and chemotactic trigger zone in man and to catecholaminergic agents in the basal ganglia and mesolimbic system in animals. Conceivably, a parallel supersensitivity in the mesolimbic area could have occurred in this patient and accounted for the psychiatric symptoms. This supersensitivity and the possibility that it may, like tardive dyskinesia, be persistant should be considered when reserpine or similar drugs are used for prolonged periods.
AB - A case is reported in which abrupt cessation of long term reserpine therapy for hypertension was followed by hallucinations and mania. Reserpine is thought to induce a denervation sensitivity to dopamine in the basal ganglia and chemotactic trigger zone in man and to catecholaminergic agents in the basal ganglia and mesolimbic system in animals. Conceivably, a parallel supersensitivity in the mesolimbic area could have occurred in this patient and accounted for the psychiatric symptoms. This supersensitivity and the possibility that it may, like tardive dyskinesia, be persistant should be considered when reserpine or similar drugs are used for prolonged periods.
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U2 - 10.1097/00005053-198208000-00011
DO - 10.1097/00005053-198208000-00011
M3 - Article
C2 - 7097268
AN - SCOPUS:0019948154
SN - 0022-3018
VL - 170
SP - 502
EP - 504
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 8
ER -