@article{38fa2c604f72467fb4c143d3aff4b8a1,
title = "Resistance in Vancomycin-Resistant Enterococci",
abstract = "Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.",
keywords = "Colonization resistance, Mechanisms of resistance, VRE, VRE colonization, Vancomycin resistant enterococcus",
author = "Miller, {William R.} and Murray, {Barbara E.} and Rice, {Louis B.} and Arias, {Cesar A.}",
note = "Funding Information: Dr W.R. Miller has received grants from Merck and Entasis Therapeutics, and honoraria from Achaogen and Shionogi. Dr B.E. Murray has received grant support from Theravance Biopharma, Paratek, and Cubist/Merck, and has served as consultant for Paratek. Dr L.B. Rice has served on data safety monitoring boards for Zavante Pharmaceuticals and VenatoRx Pharmaceuticals. Dr C.A. Arias has received grant support from Merck, MeMed Diagnostics, and Entasis Therapeutics. Funding Information: Dr W.R. Miller has received grants from Merck and Entasis Therapeutics , and honoraria from Achaogen and Shionogi. Dr B.E. Murray has received grant support from Theravance Biopharma , Paratek , and Cubist / Merck , and has served as consultant for Paratek. Dr L.B. Rice has served on data safety monitoring boards for Zavante Pharmaceuticals and VenatoRx Pharmaceuticals. Dr C.A. Arias has received grant support from Merck , MeMed Diagnostics , and Entasis Therapeutics . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = dec,
doi = "10.1016/j.idc.2020.08.004",
language = "English (US)",
volume = "34",
pages = "751--771",
journal = "Infectious Disease Clinics of North America",
issn = "0891-5520",
publisher = "W.B. Saunders Ltd",
number = "4",
}