TY - JOUR
T1 - Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy
AU - Watanabe, Kenichi
AU - Thandavarayan, Rajarajan A.
AU - Harima, Meilei
AU - Sari, Flori R.
AU - Gurusamy, Narasimman
AU - Veeraveedu, Punniyakoti T.
AU - Mito, Sayaka
AU - Arozal, Wawaimuli
AU - Sukumaran, Vijayakumar
AU - Laksmanan, Arun Prasath
AU - Soetikno, Vivian
AU - Kodama, Makoto
AU - Aizawa, Yoshifusa
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemia- induced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. Diabetes-mediated biochemical changes show cross-interaction and complex interplay culminating in the activation of several intracellular signaling molecules. Diabetic cardiomyopathy is characterized by morphologic and structural changes in the myocardium and coronary vasculature mediated by the activation of various signaling pathways. This review focuses on the oxidative stress and signaling pathways in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic cardiomyopathy.
AB - Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemia- induced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. Diabetes-mediated biochemical changes show cross-interaction and complex interplay culminating in the activation of several intracellular signaling molecules. Diabetic cardiomyopathy is characterized by morphologic and structural changes in the myocardium and coronary vasculature mediated by the activation of various signaling pathways. This review focuses on the oxidative stress and signaling pathways in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic cardiomyopathy.
KW - Apoptosis
KW - Cardiomyopathy
KW - Diabetes mellitus
KW - Hypertrophy
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=78651322164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651322164&partnerID=8YFLogxK
U2 - 10.2174/157340310793566145
DO - 10.2174/157340310793566145
M3 - Article
C2 - 22043204
AN - SCOPUS:78651322164
SN - 1573-403X
VL - 6
SP - 280
EP - 290
JO - Current Cardiology Reviews
JF - Current Cardiology Reviews
IS - 4
ER -