Role of nuclear grading in stage I renal cell carcinoma

Linda K. Green; Alberto Ayala; Jae Ro; David A. Swanson; David J. Grignon; Geoffrey G. Giacco; Vincent E. Guinee

doi:10.1016/0090-4295(89)90333-6

Role of nuclear grading in stage I renal cell carcinoma

Linda K. Green, Alberto Ayala, Jae Ro, David A. Swanson, David J. Grignon, Geoffrey G. Giacco, Vincent E. Guinee

Research output: Contribution to journal › Article › peer-review

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Abstract

Through a retrospective histologic analysis of 55 cases of Stage I renal cell carcinoma, we evaluated the usefulness of the nuclear grading system (Fuhrman, Lasky, Limas) in identifying those tumors that will eventually metastasize and kill the patient. The difference in five-year survival rates between patients with combined nuclear grade 1-3 tumors (n = 50, 91%) and grade 4 tumors (n = 5, 9%) was significant (P < 0.0046). Other predictors of death due to renal cell carcinoma included: tumor size greater than 8 cm (P < 0.001) and mitoses greater than one per 10 high-power field (P < 0.01). Within Stage I tumors, therefore, nuclear grade is an important morphologic variable for predicting long-term survival. Identification of nuclear grade 4 neoplasms may become prognostically indispensable to determine the metastatic potential of early-stage tumors and thereby to institute appropriate systemic therapy.

Original language	English (US)
Pages (from-to)	310-315
Number of pages	6
Journal	Urology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/0090-4295(89)90333-6
State	Published - Jan 1 1989

ASJC Scopus subject areas

Urology

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title = "Role of nuclear grading in stage I renal cell carcinoma",

abstract = "Through a retrospective histologic analysis of 55 cases of Stage I renal cell carcinoma, we evaluated the usefulness of the nuclear grading system (Fuhrman, Lasky, Limas) in identifying those tumors that will eventually metastasize and kill the patient. The difference in five-year survival rates between patients with combined nuclear grade 1-3 tumors (n = 50, 91%) and grade 4 tumors (n = 5, 9%) was significant (P < 0.0046). Other predictors of death due to renal cell carcinoma included: tumor size greater than 8 cm (P < 0.001) and mitoses greater than one per 10 high-power field (P < 0.01). Within Stage I tumors, therefore, nuclear grade is an important morphologic variable for predicting long-term survival. Identification of nuclear grade 4 neoplasms may become prognostically indispensable to determine the metastatic potential of early-stage tumors and thereby to institute appropriate systemic therapy.",

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AU - Green, Linda K.

AU - Ayala, Alberto

AU - Ro, Jae

AU - Swanson, David A.

AU - Grignon, David J.

AU - Giacco, Geoffrey G.

AU - Guinee, Vincent E.

PY - 1989/1/1

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N2 - Through a retrospective histologic analysis of 55 cases of Stage I renal cell carcinoma, we evaluated the usefulness of the nuclear grading system (Fuhrman, Lasky, Limas) in identifying those tumors that will eventually metastasize and kill the patient. The difference in five-year survival rates between patients with combined nuclear grade 1-3 tumors (n = 50, 91%) and grade 4 tumors (n = 5, 9%) was significant (P < 0.0046). Other predictors of death due to renal cell carcinoma included: tumor size greater than 8 cm (P < 0.001) and mitoses greater than one per 10 high-power field (P < 0.01). Within Stage I tumors, therefore, nuclear grade is an important morphologic variable for predicting long-term survival. Identification of nuclear grade 4 neoplasms may become prognostically indispensable to determine the metastatic potential of early-stage tumors and thereby to institute appropriate systemic therapy.

AB - Through a retrospective histologic analysis of 55 cases of Stage I renal cell carcinoma, we evaluated the usefulness of the nuclear grading system (Fuhrman, Lasky, Limas) in identifying those tumors that will eventually metastasize and kill the patient. The difference in five-year survival rates between patients with combined nuclear grade 1-3 tumors (n = 50, 91%) and grade 4 tumors (n = 5, 9%) was significant (P < 0.0046). Other predictors of death due to renal cell carcinoma included: tumor size greater than 8 cm (P < 0.001) and mitoses greater than one per 10 high-power field (P < 0.01). Within Stage I tumors, therefore, nuclear grade is an important morphologic variable for predicting long-term survival. Identification of nuclear grade 4 neoplasms may become prognostically indispensable to determine the metastatic potential of early-stage tumors and thereby to institute appropriate systemic therapy.

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Role of nuclear grading in stage I renal cell carcinoma

Abstract

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