Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat

Eugene V. Golanov; John D. Christensen; Donald J. Reis

doi:10.1016/S0006-8993(99)01871-5

Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat

Eugene V. Golanov, John D. Christensen, Donald J. Reis

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by ~ 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclimide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded.

Original language	English (US)
Pages (from-to)	496-500
Number of pages	5
Journal	Brain Research
Volume	842
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(99)01871-5
State	Published - Sep 25 1999

Keywords

ATP-dependent potassium channel
Cerebellar fastigial nucleus
Focal ischemia
Glibenclamide
Pre-conditioning
Stimulation

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0006-8993(99)01871-5

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title = "Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat",

abstract = "Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by ~ 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclimide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded.",

keywords = "ATP-dependent potassium channel, Cerebellar fastigial nucleus, Focal ischemia, Glibenclamide, Pre-conditioning, Stimulation",

author = "Golanov, {Eugene V.} and Christensen, {John D.} and Reis, {Donald J.}",

note = "Funding Information: This work was supported by NIH grants HL18974 to DJR and an American Heart Association Established Investigator award to EVG.",

year = "1999",

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doi = "10.1016/S0006-8993(99)01871-5",

language = "English (US)",

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TY - JOUR

T1 - Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat

AU - Golanov, Eugene V.

AU - Christensen, John D.

AU - Reis, Donald J.

N1 - Funding Information: This work was supported by NIH grants HL18974 to DJR and an American Heart Association Established Investigator award to EVG.

PY - 1999/9/25

Y1 - 1999/9/25

N2 - Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by ~ 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclimide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded.

AB - Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by ~ 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclimide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded.

KW - ATP-dependent potassium channel

KW - Cerebellar fastigial nucleus

KW - Focal ischemia

KW - Glibenclamide

KW - Pre-conditioning

KW - Stimulation

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Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat

Abstract

Keywords

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