@inbook{73f62dd243f24c269968b324e7b7a786,
title = "Role of the Histone Acetyl Transferase MOF and the Histone Deacetylase Sirtuins in Regulation of H4K16ac During DNA Damage Repair and Metabolic Programming: Implications in Cancer and Aging",
abstract = "The accurate repair of genomic damage mediated by ionizing radiation (IR), chemo- or radiomimetic drugs, or other exogenous agents, is necessary for maintenance of genome integrity, preservation of cellular viability and prevention of oncogenic transformation. Eukaryotes have conserved mechanisms designed to perceive and repair the damaged DNA quite efficiently. Among the different types of DNA damage, double strand breaks (DSB) are the most detrimental. The cellular DNA DSB response is a hierarchical signaling network that integrates damage sensing and repair with chromatin structural changes that involve a range of pre-existing and induced covalent modifications. Recent studies have revealed that pre-existing histone modifications are important contributors within this signaling/repair network. This chapter discusses the role of a critical histone acetyl transferase (HAT) known as MOF (males absent on the first) and the histone deacetylases (HDACs) Sirtuins on histone H4K16 acetylation (H4K16ac) and DNA damage repair. We also discuss the role of this important histone modification in light of metabolic rewiring and its role in regulating human pathophysiologic states.",
keywords = "Chromatin, DNA damage response, Histone H4K16ac, MOF, DNA/metabolism, Humans, Neoplasms/genetics, Histones/metabolism, Sirtuins/genetics, Histone Acetyltransferases/genetics, Histone Deacetylases/genetics, DNA Repair, Aging, Acetylation, DNA Damage",
author = "Pandita, {Tej K.} and Hunt, {Clayton R.} and Vipin Singh and Santanu Adhikary and Shruti Pandita and Siddhartha Roy and Kenneth Ramos and Chandrima Das",
note = "Funding Information: Acknowledgments This work was supported by grants GM109768 and RO1 CA129537 (T.K.P.). This work was supported in part by research grants received from Basic and Applied Research in Biophysics and Material Science (RSI 4002) from the Department of Atomic Energy; Science & Engineering Research Board (SERB)(CRG/2018/000985), Department of Science & Technology; SwarnaJayanti Fellowship (DST/SJF/LSA-02/2017-18), Department of Science and Technology; Department of Biotechnology (BT/PR28920/MED/122/176/2018); S. Ramachandran National Bioscience Award for Career Development 2019 (BT/HRD-NBA-NWB/38/2019-20), Department of Biotechnology, Govt. of India to CD. Department of Science and Technology (EMR/2016/ 006233), Govt. of India to SR. SA thanks the Council of Scientific and Industrial Research (CSIR), Govt. of India, for fellowship support. Dr. Ramos is the recipient of a GURI award from the State of Texas, USA. Funding Information: This work was supported by grants GM109768 and RO1 CA129537 (T.K.P.). This work was supported in part by research grants received from Basic and Applied Research in Biophysics and Material Science (RSI 4002) from the Department of Atomic Energy; Science & Engineering Research Board (SERB)(CRG/2018/000985), Department of Science & Technology; SwarnaJayanti Fellowship (DST/SJF/LSA-02/2017-18), Department of Science and Technology; Department of Biotechnology (BT/PR28920/MED/122/176/2018); S. Ramachandran National Bioscience Award for Career Development 2019 (BT/HRD-NBA-NWB/38/2019-20), Department of Biotechnology, Govt. of India to CD. Department of Science and Technology (EMR/2016/ 006233), Govt. of India to SR. SA thanks the Council of Scientific and Industrial Research (CSIR), Govt. of India, for fellowship support. Dr. Ramos is the recipient of a GURI award from the State of Texas, USA. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/978-3-031-07634-3_4",
language = "English (US)",
volume = "100",
series = "Sub-cellular biochemistry",
publisher = "Springer Science and Business Media B.V.",
pages = "115--141",
booktitle = "Subcellular Biochemistry",
}