Rural-Urban Differences in Cardiovascular Mortality in the US, 1999-2017

Sarah H. Cross; Mandeep R. Mehra; Deepak L. Bhatt; Khurram Nasir; Christopher J. O'Donnell; Robert M. Califf; Haider J. Warraich

doi:10.1001/jama.2020.2047

Rural-Urban Differences in Cardiovascular Mortality in the US, 1999-2017

Sarah H. Cross, Mandeep R. Mehra, Deepak L. Bhatt, Khurram Nasir, Christopher J. O'Donnell, Robert M. Califf, Haider J. Warraich

Research output: Contribution to journal › Letter › peer-review

89 Scopus citations

Original language	English (US)
Pages (from-to)	1852-1854
Number of pages	3
Journal	JAMA - Journal of the American Medical Association
Volume	323
Issue number	18
DOIs	https://doi.org/10.1001/jama.2020.2047
State	Published - May 12 2020

ASJC Scopus subject areas

Medicine(all)

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10.1001/jama.2020.2047

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@article{c3d17369ec6341c0874f32836dbc263b,

title = "Rural-Urban Differences in Cardiovascular Mortality in the US, 1999-2017",

author = "Cross, {Sarah H.} and Mehra, {Mandeep R.} and Bhatt, {Deepak L.} and Khurram Nasir and O'Donnell, {Christopher J.} and Califf, {Robert M.} and Warraich, {Haider J.}",

note = "Funding Information: Conflict of Interest Disclosures: Dr Mehra reported receiving travel support and consulting fees, paid to Brigham and Women{\textquoteright}s Hospital, from Abbott; fees for serving on a steering committee from Medtronic and Janssen (Johnson & Johnson); fees for serving on a data and safety monitoring board from Mesoblast; consulting fees from Portola, Bayer, and Triple Gene; and fees for serving as a scientific board member from NuPulseCV, Leviticus, and FineHeart. Dr Bhatt disclosed the following relationships—advisory board: Cardax, Cereno Scientific, Elsevier Practice Update Cardiology, Medscape Cardiology, PhaseBio, and Regado Biosciences; board of directors: Boston VA Research Institute, Society of Cardiovascular Patient Care, and TobeSoft; chair: American Heart Association Quality Oversight Committee; data monitoring committees: Baim Institute for Clinical Research, Cleveland Clinic, Duke Clinical Research Institute, Mayo Clinic, Mount Sinai School of Medicine, and Population Health Research Institute; honoraria: American College of Cardiology, Baim Institute for Clinical Research, Belvoir Publications, Duke Clinical Research Institute, HMP Global, Journal of the American College of Cardiology, Medtelligence/ReachMD, Population Health Research Institute, Slack Publications, Society of Cardiovascular Patient Care, and WebMD; other: Clinical Cardiology, NCDR-ACTION Registry Steering Committee, VA CART Research and Publications Committee; research funding: Abbott, Afimmune, Amarin, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Chiesi, CSL Behring, Eisai, Ethicon, Ferring Pharmaceuticals, Forest Laboratories, Fractyl, Idorsia, Ironwood, Ischemix, Lilly, Medtronic, PhaseBio, Pfizer, PLx Pharma, Regeneron, Roche, Sanofi Aventis, Synaptic, and the Medicines Company; royalties: Elsevier; site co-investigator: Biotronik, Boston Scientific, St Jude Medical, and Svelte; trustee: American College of Cardiology; and unfunded research: FlowCo, Merck, Novo Nordisk, and Takeda. Dr Nasir reported being supported by the Jerold B. Katz Academy of Translational Research. Dr Califf reported serving on the corporate board for Cytokinetics; being the board chair for the People-Centered Research Foundation; and receiving personal fees for consulting from Merck, Amgen, AstraZeneca, Biogen, Genentech, Eli Lilly, and Boehringer Ingelheim; and receiving other funding from Verily Life Sciences and Google Health. No other disclosures were reported. 1. Roth GA, Dwyer-Lindgren L, Bertozzi-Villa A, et al. Trends and patterns of geographic variation in cardiovascular mortality among US counties, 1980-2014. JAMA. 2017;317(19):1976-1992. doi:10.1001/jama.2017.4150 2. Garcia MC, Rossen LM, Bastian B, et al. Potentially excess deaths from the five leading causes of death in metropolitan and nonmetropolitan counties—United States, 2010-2017. MMWR Surveill Summ. 2019;68(10):1-11. doi:10.15585/mmwr.ss6810a1 3. US Centers for Disease Control and Prevention. CDC WONDER. Accessed January 5, 2020. https://wonder.cdc.gov 4. Sidney S, Quesenberry CP, Jaffe MG, et al. Recent trends in cardiovascular mortality in the United States and public health goals. JAMA Cardiol. 2016;1(5): 594-599. Funding Information: Additional Contributions: Patrick L. Yorio, PhD, provided statistical support for these analyses. He is affiliated with and funded by the National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. Funding Information: Funding/Support: This study was funded by the Centers for Disease Control and Prevention{\textquoteright}s National Personal Protective Technology Laboratory (contract numbers 75D30118C02646 and 75D30118C02645).",

year = "2020",

month = may,

day = "12",

doi = "10.1001/jama.2020.2047",

language = "English (US)",

volume = "323",

pages = "1852--1854",

journal = "JAMA - Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "18",

}

TY - JOUR

T1 - Rural-Urban Differences in Cardiovascular Mortality in the US, 1999-2017

AU - Cross, Sarah H.

AU - Mehra, Mandeep R.

AU - Bhatt, Deepak L.

AU - Nasir, Khurram

AU - O'Donnell, Christopher J.

AU - Califf, Robert M.

AU - Warraich, Haider J.

N1 - Funding Information: Conflict of Interest Disclosures: Dr Mehra reported receiving travel support and consulting fees, paid to Brigham and Women’s Hospital, from Abbott; fees for serving on a steering committee from Medtronic and Janssen (Johnson & Johnson); fees for serving on a data and safety monitoring board from Mesoblast; consulting fees from Portola, Bayer, and Triple Gene; and fees for serving as a scientific board member from NuPulseCV, Leviticus, and FineHeart. Dr Bhatt disclosed the following relationships—advisory board: Cardax, Cereno Scientific, Elsevier Practice Update Cardiology, Medscape Cardiology, PhaseBio, and Regado Biosciences; board of directors: Boston VA Research Institute, Society of Cardiovascular Patient Care, and TobeSoft; chair: American Heart Association Quality Oversight Committee; data monitoring committees: Baim Institute for Clinical Research, Cleveland Clinic, Duke Clinical Research Institute, Mayo Clinic, Mount Sinai School of Medicine, and Population Health Research Institute; honoraria: American College of Cardiology, Baim Institute for Clinical Research, Belvoir Publications, Duke Clinical Research Institute, HMP Global, Journal of the American College of Cardiology, Medtelligence/ReachMD, Population Health Research Institute, Slack Publications, Society of Cardiovascular Patient Care, and WebMD; other: Clinical Cardiology, NCDR-ACTION Registry Steering Committee, VA CART Research and Publications Committee; research funding: Abbott, Afimmune, Amarin, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Chiesi, CSL Behring, Eisai, Ethicon, Ferring Pharmaceuticals, Forest Laboratories, Fractyl, Idorsia, Ironwood, Ischemix, Lilly, Medtronic, PhaseBio, Pfizer, PLx Pharma, Regeneron, Roche, Sanofi Aventis, Synaptic, and the Medicines Company; royalties: Elsevier; site co-investigator: Biotronik, Boston Scientific, St Jude Medical, and Svelte; trustee: American College of Cardiology; and unfunded research: FlowCo, Merck, Novo Nordisk, and Takeda. Dr Nasir reported being supported by the Jerold B. Katz Academy of Translational Research. Dr Califf reported serving on the corporate board for Cytokinetics; being the board chair for the People-Centered Research Foundation; and receiving personal fees for consulting from Merck, Amgen, AstraZeneca, Biogen, Genentech, Eli Lilly, and Boehringer Ingelheim; and receiving other funding from Verily Life Sciences and Google Health. No other disclosures were reported. 1. Roth GA, Dwyer-Lindgren L, Bertozzi-Villa A, et al. Trends and patterns of geographic variation in cardiovascular mortality among US counties, 1980-2014. JAMA. 2017;317(19):1976-1992. doi:10.1001/jama.2017.4150 2. Garcia MC, Rossen LM, Bastian B, et al. Potentially excess deaths from the five leading causes of death in metropolitan and nonmetropolitan counties—United States, 2010-2017. MMWR Surveill Summ. 2019;68(10):1-11. doi:10.15585/mmwr.ss6810a1 3. US Centers for Disease Control and Prevention. CDC WONDER. Accessed January 5, 2020. https://wonder.cdc.gov 4. Sidney S, Quesenberry CP, Jaffe MG, et al. Recent trends in cardiovascular mortality in the United States and public health goals. JAMA Cardiol. 2016;1(5): 594-599. Funding Information: Additional Contributions: Patrick L. Yorio, PhD, provided statistical support for these analyses. He is affiliated with and funded by the National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. Funding Information: Funding/Support: This study was funded by the Centers for Disease Control and Prevention’s National Personal Protective Technology Laboratory (contract numbers 75D30118C02646 and 75D30118C02645).

PY - 2020/5/12

Y1 - 2020/5/12

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U2 - 10.1001/jama.2020.2047

DO - 10.1001/jama.2020.2047

M3 - Letter

C2 - 32396176

AN - SCOPUS:85084694004

SN - 0098-7484

VL - 323

SP - 1852

EP - 1854

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

IS - 18

ER -

Rural-Urban Differences in Cardiovascular Mortality in the US, 1999-2017

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