@article{f3034efc0ad1423fad29b0c78eb73fa7,
title = "SARS-CoV-2 Antibody Responses to the Ancestral SARS-CoV-2 Strain and Omicron BA.1 and BA.4/BA.5 Variants in Nursing Home Residents After Receipt of Bivalent COVID-19 Vaccine — Ohio and Rhode Island, September–November 2022",
abstract = "What is already known about this topic? Previous COVID-19 monovalent vaccines provided substantial reductions in COVID-19–associated morbidity and mortality among nursing home residents; however, only one half of these residents and one quarter of nursing home staff members have received the COVID-19 bivalent booster dose to date. What is added by this report? Among nursing home residents in two states, SARS-CoV-2 antibody levels waned within months after vaccination, irrespective of previous SARS-CoV-2 infection, after monovalent booster vaccination. Antibody response broadened after the COVID-19 bivalent booster for vaccinated nursing home residents among those with and without previous infection. What are the implications for public health practice? All eligible nursing home residents and staff members should follow current recommendations to receive a bivalent COVID-19 booster dose to reduce their risk for SARS-CoV-2 infection, severe COVID-19–associated illness, and death.",
keywords = "Adult, Humans, COVID-19/epidemiology, SARS-CoV-2, COVID-19 Vaccines, Vaccines, Combined, Rhode Island, Antibody Formation, Ohio, Antibodies, Viral, Nursing Homes, Antibodies, Neutralizing",
author = "Canaday, {David H.} and Oyebanji, {Oladayo A.} and White, {Elizabeth M.} and J{\"u}rgen Bosch and Clare Nugent and Igor Vishnepolskiy and Yasin Abul and Didion, {Elise M.} and Alexandra Paxitzis and Nicholas Sundheimer and Vaishnavi Ragavapuram and Dennis Wilk and Debbie Keresztesy and Yi Cao and Denis, {Kerri St} and McConeghy, {Kevin W.} and McDonald, {L. Clifford} and Jernigan, {John A.} and Eleftherios Mylonakis and Wilson, {Brigid M.} and King, {Christopher L.} and Balazs, {Alejandro B.} and Stefan Gravenstein",
note = "Funding Information: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Stefan Gravenstein and David H. Canaday are recipients of support from the U.S. Department of Veterans Affairs and investigator-initiated grants to their universities from the National Institute of Allergy and Infectious Diseases (NIAID) to study influenza vaccine and COVID-19 in the nursing home, Pfizer to study pneumococcal vaccines, and from Sanofi Pasteur and Seqirus to study influenza vaccines. Stefan Gravenstein also performs consulting work for Janssen, Merck, Moderna, Novavax, Pfizer, Sanofi, Seqirus, and Vaxart; has served on the speaker{\textquoteright}s bureaus for Seqirus and Sanofi; and was paid to chair data safety monitoring boards from Longeveron and SciClone. David H. Canaday has performed consulting work for Seqirus. Elizabeth M. White reports support from the National Institute on Aging, and membership on the Society for Post-acute and Long-term Care Medicine Workforce Development Committee and on the John Hartford Foundation Moving Forward Coalition Workforce Committee. J{\"u}rgen Bosch is the cofounder and Chief Executive Officer of InterRayBio, LLC. Yi Cao, Kerri St. Denis, and Alejandro B. Balazs report support from the Ragon Institute of Massachusetts General Hospital, the Massachusetts Institute of Technology, and Harvard University for equipment used in the current study. Kevin W. McConeghy reports grant support from Sanofi-Pasteur, Sequirus Pharmaceuticals, Genentech, and Janssen, unrelated to the current work. Eleftherios Mylonakis reports institutional support from the Biomedical Advanced Research and Development Authority, NIAID, the National Institute of General Medical Sciences, National Institutes of Health, Leidos Biomedical Research, Inc., Regeneron, Pfizer, Chemic lags/KODA therapeutics, Cidara, the National Cancer Institute, and SciClone Pharmaceuticals, and receipt of consulting fees from Basilea Pharmaceutica International, Ltd. Christopher L. King reports National Cancer Institute support for Early Drivers of Humoral Immunity to SARS-CoV-2 Infections. No other potential conflicts of interest were disclosed. Funding Information: Rosa Baier, Lewis Oscar Felix, Narchonai Ganesan, Matthew Kaczynski, Amy Recker, Fadi Shehadeh, Joyce Sunday, Brown University; Htin Aung, Lenore Carias, Michael Payne, Case Western Reserve University; Leslie Morrissey, Walther M. Pfeifer, East Side Clinical Labs, East Providence, RI. Publisher Copyright: {\textcopyright} 2023 Department of Health and Human Services. All rights reserved.",
year = "2023",
month = jan,
day = "27",
doi = "10.15585/mmwr.mm7204a4",
language = "English (US)",
volume = "72",
pages = "100--106",
journal = "Morbidity and Mortality Weekly Report",
issn = "0149-2195",
publisher = "Department of Health and Human Services",
number = "4",
}