TY - JOUR
T1 - SCAview
T2 - an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias
AU - EUROSCA study group
AU - ESMI study group
AU - RISCA study group
AU - CRC-SCA study group
AU - SCA Registry study group
AU - Uebachs, Mischa
AU - Wegner, Philipp
AU - Schaaf, Sebastian
AU - Kugai, Simon
AU - Jacobi, Heike
AU - Kuo, Sheng Han
AU - Ashizawa, Tetsuo
AU - Fluck, Juliane
AU - du Montcel, Sophie Tezenas
AU - Bauer, Peter
AU - Giunti, Paola
AU - Cook, Arron
AU - Labrum, Robyn
AU - Parkinson, Michael H.
AU - Durr, Alexandra
AU - Brice, Alexis
AU - Charles, Perrine
AU - Marelli, Cecilia
AU - Mariotti, Caterina
AU - Nanetti, Lorenzo
AU - Panzeri, Marta
AU - Rakowicz, Maria
AU - Sulek, Anna
AU - Sobanska, Anna
AU - Schmitz-Hübsch, Tanja
AU - Schöls, Ludger
AU - Hengel, Holger
AU - Baliko, Laszlo
AU - Melegh, Bela
AU - Filla, Alessandro
AU - Antenora, Antonella
AU - Infante, Jon
AU - Berciano, José
AU - van de Warrenburg, Bart P.
AU - Timmann, Dagmar
AU - Szymanski, Sandra
AU - Boesch, Sylvia
AU - Kang, Jun Suk
AU - Pandolfo, Massimo
AU - Schulz, Jörg B.
AU - Molho, Sonia
AU - Diallo, Alhassane
AU - Grobe-Einsler, Marcus
AU - Önder, Demet
AU - Raposo, Mafalda
AU - Vasconcelos, João
AU - Lima, Manuela
AU - de Almeida, Luís Pereira
AU - Silva, Patrick
AU - Cunha, Inês
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/3/31
Y1 - 2023/3/31
N2 - With SCAview, we present a prompt and comprehensive tool that enables scientists to browse large datasets of the most common spinocerebellar ataxias intuitively and without technical effort. Basic concept is a visualization of data, with a graphical handling and filtering to select and define subgroups and their comparison. Several plot types to visualize all data points resulting from the selected attributes are provided. The underlying synthetic cohort is based on clinical data from five different European and US longitudinal multicenter cohorts in spinocerebellar ataxia type 1, 2, 3, and 6 (SCA1, 2, 3, and 6) comprising > 1400 patients with overall > 5500 visits. First, we developed a common data model to integrate the clinical, demographic, and characterizing data of each source cohort. Second, the available datasets from each cohort were mapped onto the data model. Third, we created a synthetic cohort based on the cleaned dataset. With SCAview, we demonstrate the feasibility of mapping cohort data from different sources onto a common data model. The resulting browser-based visualization tool with a thoroughly graphical handling of the data offers researchers the unique possibility to visualize relationships and distributions of clinical data, to define subgroups and to further investigate them without any technical effort. Access to SCAview can be requested via the Ataxia Global Initiative and is free of charge.
AB - With SCAview, we present a prompt and comprehensive tool that enables scientists to browse large datasets of the most common spinocerebellar ataxias intuitively and without technical effort. Basic concept is a visualization of data, with a graphical handling and filtering to select and define subgroups and their comparison. Several plot types to visualize all data points resulting from the selected attributes are provided. The underlying synthetic cohort is based on clinical data from five different European and US longitudinal multicenter cohorts in spinocerebellar ataxia type 1, 2, 3, and 6 (SCA1, 2, 3, and 6) comprising > 1400 patients with overall > 5500 visits. First, we developed a common data model to integrate the clinical, demographic, and characterizing data of each source cohort. Second, the available datasets from each cohort were mapped onto the data model. Third, we created a synthetic cohort based on the cleaned dataset. With SCAview, we demonstrate the feasibility of mapping cohort data from different sources onto a common data model. The resulting browser-based visualization tool with a thoroughly graphical handling of the data offers researchers the unique possibility to visualize relationships and distributions of clinical data, to define subgroups and to further investigate them without any technical effort. Access to SCAview can be requested via the Ataxia Global Initiative and is free of charge.
KW - Observational studies
KW - Spinocerebellar ataxia (SCA)
KW - Visualization
UR - http://www.scopus.com/inward/record.url?scp=85151467845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85151467845&partnerID=8YFLogxK
U2 - 10.1007/s12311-023-01546-0
DO - 10.1007/s12311-023-01546-0
M3 - Article
C2 - 37002505
AN - SCOPUS:85151467845
SN - 1473-4222
JO - Cerebellum
JF - Cerebellum
ER -