TY - JOUR
T1 - Secreted bacterial phospholipase A2 enzymes
T2 - better living through phospholipolysis
AU - Sitkiewicz, Izabela
AU - Stockbauer, Kathryn E.
AU - Musser, James M.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - Phospholipases are ubiquitous and diverse enzymes that induce changes in membrane composition, activate the inflammatory cascade and alter cell signaling pathways. Recent evidence suggests that certain bacterial pathogens have acquired genes encoding secreted phospholipase A2 enzymes through lateral gene transfer events. The two best-studied members of this class of enzyme are ExoU and SlaA, which are produced by Pseudomonas aeruginosa and group A Streptococcus, respectively. These enzymes modulate the host inflammatory response, increase the severity of disease and otherwise alter host-pathogen interactions. We propose that a key function of ExoU and SlaA is to increase the fitness of the subclones expressing these enzymes, thereby increasing the population size of the PLA2-positive strains and enhancing the likelihood of encountering an at-risk host.
AB - Phospholipases are ubiquitous and diverse enzymes that induce changes in membrane composition, activate the inflammatory cascade and alter cell signaling pathways. Recent evidence suggests that certain bacterial pathogens have acquired genes encoding secreted phospholipase A2 enzymes through lateral gene transfer events. The two best-studied members of this class of enzyme are ExoU and SlaA, which are produced by Pseudomonas aeruginosa and group A Streptococcus, respectively. These enzymes modulate the host inflammatory response, increase the severity of disease and otherwise alter host-pathogen interactions. We propose that a key function of ExoU and SlaA is to increase the fitness of the subclones expressing these enzymes, thereby increasing the population size of the PLA2-positive strains and enhancing the likelihood of encountering an at-risk host.
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U2 - 10.1016/j.tim.2006.12.003
DO - 10.1016/j.tim.2006.12.003
M3 - Article
C2 - 17194592
AN - SCOPUS:33846688692
SN - 0966-842X
VL - 15
SP - 63
EP - 69
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 2
ER -