Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity

L. Bueno; F. De Ponti; M. Fried; G. A. Kullak-Ublick; M. A. Kwiatek; D. Pohl; E. M.M. Quigley; J. Tack; N. J. Talley

doi:10.1111/j.1365-2982.2006.00876.x

Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity

L. Bueno, F. De Ponti, M. Fried, G. A. Kullak-Ublick, M. A. Kwiatek, D. Pohl, E. M.M. Quigley, J. Tack, N. J. Talley

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

Original language	English (US)
Pages (from-to)	89-119
Number of pages	31
Journal	Neurogastroenterology and Motility
Volume	19
Issue number	SUPPL.1
DOIs	https://doi.org/10.1111/j.1365-2982.2006.00876.x
State	Published - Jan 2007

Keywords

Abdominal pain
Drugs
Enteric flora
GI disorders
Gut
Sensitivity
Serotonin

ASJC Scopus subject areas

Physiology
Gastroenterology
Neuroscience(all)

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10.1111/j.1365-2982.2006.00876.x

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title = "Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity",

abstract = "Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.",

keywords = "Abdominal pain, Drugs, Enteric flora, GI disorders, Gut, Sensitivity, Serotonin",

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AU - De Ponti, F.

AU - Fried, M.

AU - Kullak-Ublick, G. A.

AU - Kwiatek, M. A.

AU - Pohl, D.

AU - Quigley, E. M.M.

AU - Tack, J.

AU - Talley, N. J.

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N2 - Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

AB - Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

KW - Abdominal pain

KW - Drugs

KW - Enteric flora

KW - GI disorders

KW - Gut

KW - Sensitivity

KW - Serotonin

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Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Abstract

Keywords

ASJC Scopus subject areas

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