TY - GEN
T1 - Simultaneous Estimation of input functions
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
AU - Jouvie, C.
AU - De Gavriloff, S.
AU - Santiago Ribeiro, M. J.
AU - Gaura, V.
AU - Rémy, P.
AU - Zanotti-Fregonara, P.
AU - Maroy, R.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011
Y1 - 2011
N2 - Using Positron Emission Tomography for dynamic tracer mapping requires the knowledge of the arterial plasmatic activity concentration (PTAC). The reference method to obtain it is arterial sampling, not applicable in clinical studies because invasive and dangerous. The Simultaneous Estimation (SIME) method aims to estimate simultaneously the PTAC and the organ pharmacokinetic parameters from the time-activity curve of some tissues (three or four), with or without the help of some blood samples. The improvement proposed here, the B-SIME method, uses the results of the SIME on hundreds of sets of three tissues to evaluate the PTAC. Here an application for the 18F - FDG in human brain is shown; good results for the estimation of the PTAC were obtained, specially when using one late venous blood sample, for simulated and real data.
AB - Using Positron Emission Tomography for dynamic tracer mapping requires the knowledge of the arterial plasmatic activity concentration (PTAC). The reference method to obtain it is arterial sampling, not applicable in clinical studies because invasive and dangerous. The Simultaneous Estimation (SIME) method aims to estimate simultaneously the PTAC and the organ pharmacokinetic parameters from the time-activity curve of some tissues (three or four), with or without the help of some blood samples. The improvement proposed here, the B-SIME method, uses the results of the SIME on hundreds of sets of three tissues to evaluate the PTAC. Here an application for the 18F - FDG in human brain is shown; good results for the estimation of the PTAC were obtained, specially when using one late venous blood sample, for simulated and real data.
KW - FDG
KW - Positron Emission Tomography (PET)
KW - arterial input function
KW - minimal invasive measurement
KW - modeling
UR - http://www.scopus.com/inward/record.url?scp=80055037006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80055037006&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2011.5872746
DO - 10.1109/ISBI.2011.5872746
M3 - Conference contribution
AN - SCOPUS:80055037006
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1758
EP - 1761
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
Y2 - 30 March 2011 through 2 April 2011
ER -