Single-walled carbon nanotube materials as T2-weighted MRI contrast agents

Jeyarama S. Ananta; Michael L. Matson; Annie M. Tang; Trinanjana Mandal; Stephen Lin; Kelvin Wong; Stephen T. Wong; Lon J. Wilson

doi:10.1021/jp907891n

Single-walled carbon nanotube materials as T₂-weighted MRI contrast agents

Jeyarama S. Ananta, Michael L. Matson, Annie M. Tang, Trinanjana Mandal, Stephen Lin, Kelvin Wong, Stephen T. Wong, Lon J. Wilson

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

With their unique nanoscalar properties, single-walled carbon nanotube (SWNT) materials are widely studied for various biological applications. Herein, we report the efficiency of full-length HiP_co SWNTs and ultrashort SWNTs (US-tubes) as T₂-weighted MRI contrast agents. Analysis has concluded that the superparamagnetic SWNT materials (especially US-tubes) are a new class of high-efficacy contrast agents having performance contributions from both the iron catalyst nanoparticles (originating from the synthesis of SWNT materials) and the carbon SWNT material itself. The superparamagnetic US-tubes with their short length (<100 nm), negligible metal content (<1% Fe (wt %)), and superior T₂ relaxation efficiency (T₂ ) 31.7 ms per mg SWNT at 3 T and 37 °C) are the most promising candidates for advanced applications such as molecular and cellular imaging using MRI.

Original language	English (US)
Pages (from-to)	19369-19372
Number of pages	4
Journal	Journal of Physical Chemistry C
Volume	113
Issue number	45
DOIs	https://doi.org/10.1021/jp907891n
State	Published - 2009

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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title = "Single-walled carbon nanotube materials as T2-weighted MRI contrast agents",

abstract = "With their unique nanoscalar properties, single-walled carbon nanotube (SWNT) materials are widely studied for various biological applications. Herein, we report the efficiency of full-length HiPco SWNTs and ultrashort SWNTs (US-tubes) as T2-weighted MRI contrast agents. Analysis has concluded that the superparamagnetic SWNT materials (especially US-tubes) are a new class of high-efficacy contrast agents having performance contributions from both the iron catalyst nanoparticles (originating from the synthesis of SWNT materials) and the carbon SWNT material itself. The superparamagnetic US-tubes with their short length (<100 nm), negligible metal content (<1% Fe (wt %)), and superior T2 relaxation efficiency (T2 ) 31.7 ms per mg SWNT at 3 T and 37 °C) are the most promising candidates for advanced applications such as molecular and cellular imaging using MRI.",

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AU - Ananta, Jeyarama S.

AU - Matson, Michael L.

AU - Tang, Annie M.

AU - Mandal, Trinanjana

AU - Lin, Stephen

AU - Wong, Kelvin

AU - Wong, Stephen T.

AU - Wilson, Lon J.

PY - 2009

Y1 - 2009

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AB - With their unique nanoscalar properties, single-walled carbon nanotube (SWNT) materials are widely studied for various biological applications. Herein, we report the efficiency of full-length HiPco SWNTs and ultrashort SWNTs (US-tubes) as T2-weighted MRI contrast agents. Analysis has concluded that the superparamagnetic SWNT materials (especially US-tubes) are a new class of high-efficacy contrast agents having performance contributions from both the iron catalyst nanoparticles (originating from the synthesis of SWNT materials) and the carbon SWNT material itself. The superparamagnetic US-tubes with their short length (<100 nm), negligible metal content (<1% Fe (wt %)), and superior T2 relaxation efficiency (T2 ) 31.7 ms per mg SWNT at 3 T and 37 °C) are the most promising candidates for advanced applications such as molecular and cellular imaging using MRI.

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Single-walled carbon nanotube materials as T₂-weighted MRI contrast agents

Abstract

ASJC Scopus subject areas

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