TY - JOUR
T1 - Sleep disorders in spinocerebellar ataxia type 10
AU - London, Ester
AU - Camargo, Carlos H.F.
AU - Zanatta, Alessandra
AU - Crippa, Ana C.
AU - Raskin, Salmo
AU - Munhoz, Renato P.
AU - Ashizawa, Tetsuo
AU - Teive, Hélio A.G.
N1 - Publisher Copyright:
© 2018 European Sleep Research Society
PY - 2018/10
Y1 - 2018/10
N2 - As sleep disturbances have been reported in spinocerebellar ataxias (SCAs), including types SCA1, SCA2, SCA3, SCA6 and SCA13, identification and management of these disturbances can help minimise their impact on SCA patients' overall body functions and quality of life. To our knowledge, there are no studies that investigate sleep disturbances in SCA10. Therefore, the aim of this study was to assess sleep disturbances in patients with SCA10. Twenty-three SCA10 patients and 23 healthy controls were recruited. Patients were evaluated in terms of their demographic and clinical data, including disease severity (Scale for the Assessment and Rating of Ataxia, SARA) and excessive daytime sleepiness (Epworth Sleepiness Scale, ESS), and underwent polysomnography. SCA10 patients had longer rapid eye movement (REM) sleep (p =.04) and more REM arousals than controls (p<.0001). There was a correlation of REM sleep onset with the age of onset of symptoms (r =.459), and with disease duration (r = −.4305). There also was correlation between the respiratory disturbance index (RDI) and SARA (r = −.4013), and a strong indirect correlation between arousal index and age at onset of symptoms (r = −.5756). In conclusion, SCA10 patients had sleep abnormalities that included more REM arousals and higher RDI than controls. Our SCA10 patients had sleep disorders related to shorter disease duration and lower severity of ataxia, in a pattern similar to that of other neurodegenerative diseases.
AB - As sleep disturbances have been reported in spinocerebellar ataxias (SCAs), including types SCA1, SCA2, SCA3, SCA6 and SCA13, identification and management of these disturbances can help minimise their impact on SCA patients' overall body functions and quality of life. To our knowledge, there are no studies that investigate sleep disturbances in SCA10. Therefore, the aim of this study was to assess sleep disturbances in patients with SCA10. Twenty-three SCA10 patients and 23 healthy controls were recruited. Patients were evaluated in terms of their demographic and clinical data, including disease severity (Scale for the Assessment and Rating of Ataxia, SARA) and excessive daytime sleepiness (Epworth Sleepiness Scale, ESS), and underwent polysomnography. SCA10 patients had longer rapid eye movement (REM) sleep (p =.04) and more REM arousals than controls (p<.0001). There was a correlation of REM sleep onset with the age of onset of symptoms (r =.459), and with disease duration (r = −.4305). There also was correlation between the respiratory disturbance index (RDI) and SARA (r = −.4013), and a strong indirect correlation between arousal index and age at onset of symptoms (r = −.5756). In conclusion, SCA10 patients had sleep abnormalities that included more REM arousals and higher RDI than controls. Our SCA10 patients had sleep disorders related to shorter disease duration and lower severity of ataxia, in a pattern similar to that of other neurodegenerative diseases.
KW - SCA10
KW - arousal index
KW - rapid eye movement sleep disorders
KW - respiratory disturbances
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U2 - 10.1111/jsr.12688
DO - 10.1111/jsr.12688
M3 - Article
C2 - 29624773
AN - SCOPUS:85044968443
SN - 0962-1105
VL - 27
JO - Journal of Sleep Research
JF - Journal of Sleep Research
IS - 5
M1 - e12688
ER -