TY - JOUR
T1 - Sphingolipid signaling in metabolic disorders
AU - Hla, Timothy
AU - Dannenberg, Andrew J.
N1 - Funding Information:
This work is supported by NIH grants (HL49094, HL67330, HL70694, HL89934) to T.H. and NIH grant CA154481, the Breast Cancer Research Foundation, and the Botwinick-Wolfensohn Foundation to A.J.D.
PY - 2012/10/3
Y1 - 2012/10/3
N2 - Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being recognized as critical players in metabolic diseases. This review focuses on recent advances in cellular and physiological mechanisms of sphingolipid regulation and how sphingolipid signaling influences metabolic diseases. Progress in this area may contribute to new understanding and therapeutic options in complex diseases such as atherosclerosis, diabetes, metabolic syndromes, and cancer.
AB - Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being recognized as critical players in metabolic diseases. This review focuses on recent advances in cellular and physiological mechanisms of sphingolipid regulation and how sphingolipid signaling influences metabolic diseases. Progress in this area may contribute to new understanding and therapeutic options in complex diseases such as atherosclerosis, diabetes, metabolic syndromes, and cancer.
UR - http://www.scopus.com/inward/record.url?scp=84867096429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867096429&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2012.06.017
DO - 10.1016/j.cmet.2012.06.017
M3 - Review article
C2 - 22982021
AN - SCOPUS:84867096429
SN - 1550-4131
VL - 16
SP - 420
EP - 434
JO - Cell Metabolism
JF - Cell Metabolism
IS - 4
ER -