Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing

Wenlan Qiu; Long Chang; Yu Chi Liang; Julia Litvinov; Jing Guo; Yi Ting Chen; Binh Vu; Katerina Kourentzi; Shoujun Xu; T. Randall Lee; Youli Zu; Richard C. Willson; Dmitri Litvinov

doi:10.1016/j.sna.2017.08.018

Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing

Wenlan Qiu, Long Chang, Yu Chi Liang, Julia Litvinov, Jing Guo, Yi Ting Chen, Binh Vu, Katerina Kourentzi, Shoujun Xu, T. Randall Lee, Youli Zu, Richard C. Willson, Dmitri Litvinov

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A magnetoresistive sensor platform for the detection of individual magnetic reporter particles is presented. The sensing scheme is based on the detection of the shift in the sensor's magnetoresistance-switching field in the presence of magnetic particle(s). A bottom-pinned spin-valve multilayer (Co/Ru/Co)/Cu/(Co/Ru/Co) device structure (with Ta/Ru seed and Ta capping layers) used for the sensor was deposited using ultra-high vacuum magnetron sputtering and patterned using conventional microfabrication techniques. Inexpensive electronics to measure device magnetoresistance (using DC currents) was used for testing. The detection of individual 500 nm Fe₃O₄ nanoparticles as well as the detection of up to ten (10) nanoparticles was demonstrated and verified using scanning electron microscopy (SEM). The developed sensors are readily integratable into a biosensing platform for the detection of biomolecules at ultra-low concentration using magnetic nanoparticles as reporters.

Original language	English (US)
Pages (from-to)	174-180
Number of pages	7
Journal	Sensors and Actuators, A: Physical
Volume	265
DOIs	https://doi.org/10.1016/j.sna.2017.08.018
State	Published - Oct 1 2017

Keywords

Bioinstrumentation
Biosensor
Magnetic particle detection
Magnetoresistive sensors

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering

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10.1016/j.sna.2017.08.018

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title = "Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing",

abstract = "A magnetoresistive sensor platform for the detection of individual magnetic reporter particles is presented. The sensing scheme is based on the detection of the shift in the sensor's magnetoresistance-switching field in the presence of magnetic particle(s). A bottom-pinned spin-valve multilayer (Co/Ru/Co)/Cu/(Co/Ru/Co) device structure (with Ta/Ru seed and Ta capping layers) used for the sensor was deposited using ultra-high vacuum magnetron sputtering and patterned using conventional microfabrication techniques. Inexpensive electronics to measure device magnetoresistance (using DC currents) was used for testing. The detection of individual 500 nm Fe3O4 nanoparticles as well as the detection of up to ten (10) nanoparticles was demonstrated and verified using scanning electron microscopy (SEM). The developed sensors are readily integratable into a biosensing platform for the detection of biomolecules at ultra-low concentration using magnetic nanoparticles as reporters.",

keywords = "Bioinstrumentation, Biosensor, Magnetic particle detection, Magnetoresistive sensors",

author = "Wenlan Qiu and Long Chang and Liang, {Yu Chi} and Julia Litvinov and Jing Guo and Chen, {Yi Ting} and Binh Vu and Katerina Kourentzi and Shoujun Xu and Lee, {T. Randall} and Youli Zu and Willson, {Richard C.} and Dmitri Litvinov",

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year = "2017",

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day = "1",

doi = "10.1016/j.sna.2017.08.018",

language = "English (US)",

volume = "265",

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T1 - Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing

AU - Qiu, Wenlan

AU - Chang, Long

AU - Liang, Yu Chi

AU - Litvinov, Julia

AU - Guo, Jing

AU - Chen, Yi Ting

AU - Vu, Binh

AU - Kourentzi, Katerina

AU - Xu, Shoujun

AU - Lee, T. Randall

AU - Zu, Youli

AU - Willson, Richard C.

AU - Litvinov, Dmitri

PY - 2017/10/1

Y1 - 2017/10/1

N2 - A magnetoresistive sensor platform for the detection of individual magnetic reporter particles is presented. The sensing scheme is based on the detection of the shift in the sensor's magnetoresistance-switching field in the presence of magnetic particle(s). A bottom-pinned spin-valve multilayer (Co/Ru/Co)/Cu/(Co/Ru/Co) device structure (with Ta/Ru seed and Ta capping layers) used for the sensor was deposited using ultra-high vacuum magnetron sputtering and patterned using conventional microfabrication techniques. Inexpensive electronics to measure device magnetoresistance (using DC currents) was used for testing. The detection of individual 500 nm Fe3O4 nanoparticles as well as the detection of up to ten (10) nanoparticles was demonstrated and verified using scanning electron microscopy (SEM). The developed sensors are readily integratable into a biosensing platform for the detection of biomolecules at ultra-low concentration using magnetic nanoparticles as reporters.

AB - A magnetoresistive sensor platform for the detection of individual magnetic reporter particles is presented. The sensing scheme is based on the detection of the shift in the sensor's magnetoresistance-switching field in the presence of magnetic particle(s). A bottom-pinned spin-valve multilayer (Co/Ru/Co)/Cu/(Co/Ru/Co) device structure (with Ta/Ru seed and Ta capping layers) used for the sensor was deposited using ultra-high vacuum magnetron sputtering and patterned using conventional microfabrication techniques. Inexpensive electronics to measure device magnetoresistance (using DC currents) was used for testing. The detection of individual 500 nm Fe3O4 nanoparticles as well as the detection of up to ten (10) nanoparticles was demonstrated and verified using scanning electron microscopy (SEM). The developed sensors are readily integratable into a biosensing platform for the detection of biomolecules at ultra-low concentration using magnetic nanoparticles as reporters.

KW - Bioinstrumentation

KW - Biosensor

KW - Magnetic particle detection

KW - Magnetoresistive sensors

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JO - Sensors and Actuators, A: Physical

JF - Sensors and Actuators, A: Physical

ER -

Spin-Valve based magnetoresistive nanoparticle detector for applications in biosensing

Abstract

Keywords

ASJC Scopus subject areas

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