Stage-Based Management of Type 2 Diabetes Mellitus with Heart Failure

Patricia Mejia Osuna; Spandana J. Brown; Laila S. Tabatabai; Dale J. Hamilton

doi:10.14797/mdcj-14-4-257

Stage-Based Management of Type 2 Diabetes Mellitus with Heart Failure

Patricia Mejia Osuna, Spandana J. Brown, Laila S. Tabatabai, Dale J. Hamilton

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Type 2 diabetes negatively impacts heart failure outcomes. Insulin resistance, central adiposity, dyslipidemia, and altered cellular substrate metabolism each have a mechanistic role. Management strategies focused solely on glycemic control have had limited success. However, three new classes of drugs, each with several options, offer the promise of improved diabetes management in heart failure. Unlike earlier classes, these medications have had favorable cardiovascular outcomes. In this review, we present a therapeutic guide for metabolic treatment based on the stages of heart failure.

Original language	English (US)
Pages (from-to)	257-265
Number of pages	9
Journal	Methodist DeBakey cardiovascular journal
Volume	14
Issue number	4
DOIs	https://doi.org/10.14797/mdcj-14-4-257
State	Published - Oct 1 2018

Keywords

DPP-4 inhibitors
GLP-1 agonists
SGLT2 inhibitors
heart failure
therapeutic options
type 2 diabetes

ASJC Scopus subject areas

Medicine(all)

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10.14797/mdcj-14-4-257

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title = "Stage-Based Management of Type 2 Diabetes Mellitus with Heart Failure",

abstract = "Type 2 diabetes negatively impacts heart failure outcomes. Insulin resistance, central adiposity, dyslipidemia, and altered cellular substrate metabolism each have a mechanistic role. Management strategies focused solely on glycemic control have had limited success. However, three new classes of drugs, each with several options, offer the promise of improved diabetes management in heart failure. Unlike earlier classes, these medications have had favorable cardiovascular outcomes. In this review, we present a therapeutic guide for metabolic treatment based on the stages of heart failure.",

keywords = "DPP-4 inhibitors, GLP-1 agonists, SGLT2 inhibitors, heart failure, therapeutic options, type 2 diabetes",

author = "Osuna, {Patricia Mejia} and Brown, {Spandana J.} and Tabatabai, {Laila S.} and Hamilton, {Dale J.}",

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doi = "10.14797/mdcj-14-4-257",

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AU - Osuna, Patricia Mejia

AU - Brown, Spandana J.

AU - Tabatabai, Laila S.

AU - Hamilton, Dale J.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Type 2 diabetes negatively impacts heart failure outcomes. Insulin resistance, central adiposity, dyslipidemia, and altered cellular substrate metabolism each have a mechanistic role. Management strategies focused solely on glycemic control have had limited success. However, three new classes of drugs, each with several options, offer the promise of improved diabetes management in heart failure. Unlike earlier classes, these medications have had favorable cardiovascular outcomes. In this review, we present a therapeutic guide for metabolic treatment based on the stages of heart failure.

AB - Type 2 diabetes negatively impacts heart failure outcomes. Insulin resistance, central adiposity, dyslipidemia, and altered cellular substrate metabolism each have a mechanistic role. Management strategies focused solely on glycemic control have had limited success. However, three new classes of drugs, each with several options, offer the promise of improved diabetes management in heart failure. Unlike earlier classes, these medications have had favorable cardiovascular outcomes. In this review, we present a therapeutic guide for metabolic treatment based on the stages of heart failure.

KW - DPP-4 inhibitors

KW - GLP-1 agonists

KW - SGLT2 inhibitors

KW - heart failure

KW - therapeutic options

KW - type 2 diabetes

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JO - Methodist DeBakey cardiovascular journal

JF - Methodist DeBakey cardiovascular journal

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ER -

Stage-Based Management of Type 2 Diabetes Mellitus with Heart Failure

Abstract

Keywords

ASJC Scopus subject areas

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