TY - JOUR
T1 - Studies on the Metabolism of C19 Steroids in Rat Liver Biosynthesis of Saturated 17‐Oxo‐C19O3 Steroids in Rat Liver Microsomes
AU - Gustafsson, Jan‐Åke
AU - Lisboa, Belisário P.
PY - 1970/11
Y1 - 1970/11
N2 - After incubation of 4‐androstene‐3,17‐dione, 5α‐androstane‐3,17‐dione, 3α‐hydroxy‐5α‐androstan‐17‐one and 3β‐hydroxy‐5α‐androstan‐17‐one with rat liver microsomes the following steroids were isolated and identified by thin‐layer chromatography and by gas chromatography‐mass spectrometry: 3α‐ and 3β, 16α‐dihydroxy‐5α‐androstan‐17‐one, 3α‐ and 3β, 7α‐dihydroxy‐5α‐androstan‐17‐one, 3β, 7β‐dihydroxy‐5α‐androstan‐17‐one and 3β, 17β‐dihydroxy‐5α‐androstan‐16‐one. The importance of the 17‐oxo and 17β‐hydroxy pathways in the metabolism of C19 steroids in rat liver is discussed.
AB - After incubation of 4‐androstene‐3,17‐dione, 5α‐androstane‐3,17‐dione, 3α‐hydroxy‐5α‐androstan‐17‐one and 3β‐hydroxy‐5α‐androstan‐17‐one with rat liver microsomes the following steroids were isolated and identified by thin‐layer chromatography and by gas chromatography‐mass spectrometry: 3α‐ and 3β, 16α‐dihydroxy‐5α‐androstan‐17‐one, 3α‐ and 3β, 7α‐dihydroxy‐5α‐androstan‐17‐one, 3β, 7β‐dihydroxy‐5α‐androstan‐17‐one and 3β, 17β‐dihydroxy‐5α‐androstan‐16‐one. The importance of the 17‐oxo and 17β‐hydroxy pathways in the metabolism of C19 steroids in rat liver is discussed.
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U2 - 10.1111/j.1432-1033.1970.tb01105.x
DO - 10.1111/j.1432-1033.1970.tb01105.x
M3 - Article
C2 - 5477292
AN - SCOPUS:0014883943
SN - 0014-2956
VL - 16
SP - 475
EP - 480
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
IS - 3
ER -