18F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management

Harikrishna Kommidi; Hua Guo; Fuad Nurili; Yogindra Vedvyas; Moonsoo M. Jin; Timothy D. McClure; Behfar Ehdaie; Haluk B. Sayman; Oguz Akin; Omer Aras; Richard Ting

doi:10.1021/acs.jmedchem.8b00240

¹⁸F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management

Harikrishna Kommidi, Hua Guo, Fuad Nurili, Yogindra Vedvyas, Moonsoo M. Jin, Timothy D. McClure, Behfar Ehdaie, Haluk B. Sayman, Oguz Akin, Omer Aras, Richard Ting

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41 Scopus citations

Abstract

[^18/19F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [¹⁹F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [¹⁹F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [¹⁸F]-PET. PC3-PIP (PSMA-positive, EC₅₀ = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [^18/19F]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed.

Original language	English (US)
Pages (from-to)	4256-4262
Number of pages	7
Journal	Journal of Medicinal Chemistry
Volume	61
Issue number	9
DOIs	https://doi.org/10.1021/acs.jmedchem.8b00240
State	Published - May 10 2018

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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@article{27302a388ed145af98f02af8a07ac834,

title = "18F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management",

abstract = "[18/19F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [18/19F]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed.",

author = "Harikrishna Kommidi and Hua Guo and Fuad Nurili and Yogindra Vedvyas and Jin, {Moonsoo M.} and McClure, {Timothy D.} and Behfar Ehdaie and Sayman, {Haluk B.} and Oguz Akin and Omer Aras and Richard Ting",

note = "Funding Information: The project was supported by National Institutes of Health Grants EB013904, R01CA178007, and P30CA008748. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = may,

day = "10",

doi = "10.1021/acs.jmedchem.8b00240",

language = "English (US)",

volume = "61",

pages = "4256--4262",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "9",

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TY - JOUR

T1 - 18F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management

AU - Kommidi, Harikrishna

AU - Guo, Hua

AU - Nurili, Fuad

AU - Vedvyas, Yogindra

AU - Jin, Moonsoo M.

AU - McClure, Timothy D.

AU - Ehdaie, Behfar

AU - Sayman, Haluk B.

AU - Akin, Oguz

AU - Aras, Omer

AU - Ting, Richard

PY - 2018/5/10

Y1 - 2018/5/10

N2 - [18/19F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [18/19F]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed.

AB - [18/19F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [18/19F]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed.

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DO - 10.1021/acs.jmedchem.8b00240

M3 - Article

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AN - SCOPUS:85046786143

SN - 0022-2623

VL - 61

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EP - 4262

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 9

ER -

¹⁸F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management

Abstract

ASJC Scopus subject areas

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