Abstract
Trichloroacetyl isocyanate reacts rapidly and quantitatively with both acid and hydroxyl chain ends to form derivatives that can be readily determined by 1H-NMR spectroscopy. This method provides a convenient mean for characterization of polyethylene terephthalate (PET) end-groups. The 1H-NMR spectroscopy has been applied to describe the chemical aging of the PET vascular prostheses by determination of the hydroxyl and carboxyl end-group concentrations and therefore the macromolecular weight. To validate 1H-NMR results, we used chemical titration of the end-groups and classical viscosimetric method as complementary techniques. The analyses made on the explants of different lifetime demonstrated a significant deterioration compared with the virgin prostheses. A high degradation of macromolecular weight is observed. This phenomenon is explained by a random scission of the ester linkages.
Original language | English (US) |
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Pages (from-to) | 939-952 |
Number of pages | 14 |
Journal | Journal of Biomedical Materials Research - Part A |
Volume | 91 |
Issue number | 3 |
DOIs | |
State | Published - Dec 2009 |
Keywords
- Chemical aging
- H-NMR spectroscopy
- Macromolecular weight
- Polyethylene terephthalate
- Vascular prosthesis
ASJC Scopus subject areas
- Ceramics and Composites
- Biomaterials
- Biomedical Engineering
- Metals and Alloys