99mtc glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in scid mice

Zhonglin Liu; Gail D. Stevenson; Harrison H. Barrett; George A. Kastis; Michel Bettan; Lars R. Furenlid; Donald W. Wilson; James M. Woolfenden; Koon Yan Pak

doi:10.1097/01.mnm.0000130243.06821.90

^99mtc glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in scid mice

Zhonglin Liu, Gail D. Stevenson, Harrison H. Barrett, George A. Kastis, Michel Bettan, Lars R. Furenlid, Donald W. Wilson, James M. Woolfenden, Koon Yan Pak

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Previous studies have showed that ^99mTc labelled glucarate (GLA) might be an agent for non-invasive detection of breast tumours. In xenografted BT20 breast tumours, GLA was found to have higher uptake than ^99mTc sestamibi (MIBI). It is unclear whether GLA can localize in all cell line breast cancer xenografts, as well as breast tumours with multidrug resistance (MDR). The present study aimed to investigate the properties of GLA in detecting drug sensitive and drug resistant MCF7 breast cancer xenografts in mice by using dynamic single photon emission computed tomography (SPECT) imaging.

Original language	English (US)
Pages (from-to)	711-720
Number of pages	10
Journal	Nuclear medicine communications
Volume	25
Issue number	7
DOIs	https://doi.org/10.1097/01.mnm.0000130243.06821.90
State	Published - Jul 2004

Keywords

Tc glucarate
Tc sestamibi
Breast cancer
High-resolution SPECT
Multidrug resistant
SCID mice

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/01.mnm.0000130243.06821.90

Cite this

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title = "99mtc glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in scid mice",

abstract = "Previous studies have showed that 99mTc labelled glucarate (GLA) might be an agent for non-invasive detection of breast tumours. In xenografted BT20 breast tumours, GLA was found to have higher uptake than 99mTc sestamibi (MIBI). It is unclear whether GLA can localize in all cell line breast cancer xenografts, as well as breast tumours with multidrug resistance (MDR). The present study aimed to investigate the properties of GLA in detecting drug sensitive and drug resistant MCF7 breast cancer xenografts in mice by using dynamic single photon emission computed tomography (SPECT) imaging.",

keywords = "Tc glucarate, Tc sestamibi, Breast cancer, High-resolution SPECT, Multidrug resistant, SCID mice",

author = "Zhonglin Liu and Stevenson, {Gail D.} and Barrett, {Harrison H.} and Kastis, {George A.} and Michel Bettan and Furenlid, {Lars R.} and Wilson, {Donald W.} and Woolfenden, {James M.} and Pak, {Koon Yan}",

year = "2004",

month = jul,

doi = "10.1097/01.mnm.0000130243.06821.90",

language = "English (US)",

volume = "25",

pages = "711--720",

journal = "Nuclear medicine communications",

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T1 - 99mtc glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in scid mice

AU - Liu, Zhonglin

AU - Stevenson, Gail D.

AU - Barrett, Harrison H.

AU - Kastis, George A.

AU - Bettan, Michel

AU - Furenlid, Lars R.

AU - Wilson, Donald W.

AU - Woolfenden, James M.

AU - Pak, Koon Yan

PY - 2004/7

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AB - Previous studies have showed that 99mTc labelled glucarate (GLA) might be an agent for non-invasive detection of breast tumours. In xenografted BT20 breast tumours, GLA was found to have higher uptake than 99mTc sestamibi (MIBI). It is unclear whether GLA can localize in all cell line breast cancer xenografts, as well as breast tumours with multidrug resistance (MDR). The present study aimed to investigate the properties of GLA in detecting drug sensitive and drug resistant MCF7 breast cancer xenografts in mice by using dynamic single photon emission computed tomography (SPECT) imaging.

KW - Tc glucarate

KW - Tc sestamibi

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KW - High-resolution SPECT

KW - Multidrug resistant

KW - SCID mice

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