Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features

Haneen T. Salah; Julieta A. D'ardis; Donghwa Baek; Mary R. Schwartz; Alberto G. Ayala; Jae Y. Ro

doi:10.1016/j.anndiagpath.2022.151937

Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features

Haneen T. Salah, Julieta A. D'ardis, Donghwa Baek, Mary R. Schwartz, Alberto G. Ayala, Jae Y. Ro

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare mesenchymal tumor of borderline malignancy. It generally involves superficial soft tissue, with a predilection to the lower extremities. Microscopically this tumor is characterized by a fascicular and storiform growth pattern, spindled to epithelioid cells, nuclear atypia with pleomorphism, and eosinophilic granular, and fibrillar to glassy cytoplasm. Strong diffuse immunoreactivity for CD34 is very characteristic of this entity. Due to under-recognition, this tumor is generally underreported. Additionally, cases of recurrence are rarely reported in the literature. We will comprehensively review the English language literature on all reported cases of SCPFT, with emphasis on recurrence.

Original language	English (US)
Article number	151937
Pages (from-to)	151937
Journal	Annals of Diagnostic Pathology
Volume	58
DOIs	https://doi.org/10.1016/j.anndiagpath.2022.151937
State	Published - Jun 2022

Keywords

CD34-positive
Fibroblastic tumors
Local recurrence
SCPFT
Superficial location
Antigens, CD34
Neoplasms, Connective and Soft Tissue
Neoplasms, Fibrous Tissue/pathology
Epithelioid Cells/pathology
Soft Tissue Neoplasms/diagnosis
Humans
Biomarkers, Tumor

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.anndiagpath.2022.151937

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title = "Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features",

abstract = "Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare mesenchymal tumor of borderline malignancy. It generally involves superficial soft tissue, with a predilection to the lower extremities. Microscopically this tumor is characterized by a fascicular and storiform growth pattern, spindled to epithelioid cells, nuclear atypia with pleomorphism, and eosinophilic granular, and fibrillar to glassy cytoplasm. Strong diffuse immunoreactivity for CD34 is very characteristic of this entity. Due to under-recognition, this tumor is generally underreported. Additionally, cases of recurrence are rarely reported in the literature. We will comprehensively review the English language literature on all reported cases of SCPFT, with emphasis on recurrence.",

keywords = "CD34-positive, Fibroblastic tumors, Local recurrence, SCPFT, Superficial location, Antigens, CD34, Neoplasms, Connective and Soft Tissue, Neoplasms, Fibrous Tissue/pathology, Epithelioid Cells/pathology, Soft Tissue Neoplasms/diagnosis, Humans, Biomarkers, Tumor",

author = "Salah, {Haneen T.} and D'ardis, {Julieta A.} and Donghwa Baek and Schwartz, {Mary R.} and Ayala, {Alberto G.} and Ro, {Jae Y.}",

year = "2022",

month = jun,

doi = "10.1016/j.anndiagpath.2022.151937",

language = "English (US)",

volume = "58",

pages = "151937",

journal = "Annals of Diagnostic Pathology",

issn = "1092-9134",

publisher = "W.B. Saunders Ltd",

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T1 - Superficial CD34-positive fibroblastic tumor (SCPFT)

T2 - A review of pathological and clinical features

AU - Salah, Haneen T.

AU - D'ardis, Julieta A.

AU - Baek, Donghwa

AU - Schwartz, Mary R.

AU - Ayala, Alberto G.

AU - Ro, Jae Y.

PY - 2022/6

Y1 - 2022/6

N2 - Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare mesenchymal tumor of borderline malignancy. It generally involves superficial soft tissue, with a predilection to the lower extremities. Microscopically this tumor is characterized by a fascicular and storiform growth pattern, spindled to epithelioid cells, nuclear atypia with pleomorphism, and eosinophilic granular, and fibrillar to glassy cytoplasm. Strong diffuse immunoreactivity for CD34 is very characteristic of this entity. Due to under-recognition, this tumor is generally underreported. Additionally, cases of recurrence are rarely reported in the literature. We will comprehensively review the English language literature on all reported cases of SCPFT, with emphasis on recurrence.

AB - Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare mesenchymal tumor of borderline malignancy. It generally involves superficial soft tissue, with a predilection to the lower extremities. Microscopically this tumor is characterized by a fascicular and storiform growth pattern, spindled to epithelioid cells, nuclear atypia with pleomorphism, and eosinophilic granular, and fibrillar to glassy cytoplasm. Strong diffuse immunoreactivity for CD34 is very characteristic of this entity. Due to under-recognition, this tumor is generally underreported. Additionally, cases of recurrence are rarely reported in the literature. We will comprehensively review the English language literature on all reported cases of SCPFT, with emphasis on recurrence.

KW - CD34-positive

KW - Fibroblastic tumors

KW - Local recurrence

KW - SCPFT

KW - Superficial location

KW - Antigens, CD34

KW - Neoplasms, Connective and Soft Tissue

KW - Neoplasms, Fibrous Tissue/pathology

KW - Epithelioid Cells/pathology

KW - Soft Tissue Neoplasms/diagnosis

KW - Humans

KW - Biomarkers, Tumor

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U2 - 10.1016/j.anndiagpath.2022.151937

DO - 10.1016/j.anndiagpath.2022.151937

M3 - Review article

C2 - 35344860

AN - SCOPUS:85126921223

SN - 1092-9134

VL - 58

SP - 151937

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

M1 - 151937

ER -

Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features

Abstract

Keywords

ASJC Scopus subject areas

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