@article{29e0d27fbd2d49b9a5b973b84d0ac64d,
title = "Tedizolid as step-down therapy following daptomycin versus continuation of daptomycin against enterococci and methicillin- And vancomycin-resistant Staphylococcus aureus in a rat endocarditis model",
abstract = "Tedizolid (TZD) and daptomycin (DAP) were assessed in a rat endocarditis model against Enterococcus faecalis, Enterococcus faecium (resistant to vancomycin and ampicillin), and Staphylococcus aureus. As a monotherapy, TZD for 5 days was not effective in a comparison with no-treatment controls, while DAP for 5 days was significantly effective against these bacteria. Step-down therapy (DAP for 3 days followed by TZD for 2 days) was as effective as DAP for 5 days and was comparable to 3 days of DAP plus ceftriaxone against all bacteria and to 3 days of DAP plus gentamicin against E. faecalis OG1RF.",
keywords = "Daptomycin, E. faecalis, E. faecium, Enterococci, Experimental endocarditis, MRSA/VRSA, Staphylococci, Tedizolid",
author = "Singh, {Kavindra V.} and Arias, {Cesar A.} and Murray, {Barbara E.}",
note = "Funding Information: This work was supported by Merck, Inc., in the form of an investigator-initiated grant to the University of Texas Health Science Center, McGovern Medical School (K.V.S., principal investigator). C.A.A. is supported in part by grants K24-AI121296, R01AI134637, and R21AI143229. B.E.M. and K.V.S. are in part supported by grant R21AI133289-01A1 from the NIAID.*%blankline%* Funding Information: This work was supported by Merck, Inc., in the form of an investigator-initiated grant to the University of Texas Health Science Center, McGovern Medical School (K.V.S., principal investigator). C.A.A. is supported in part by grants K24-AI121296, R01AI134637, and R21AI143229. B.E.M. and K.V.S. are in part supported by grant R21AI133289-01A1 from the NIAID. We thank Karen Jacques-Palaz for technical assistance. Publisher Copyright: {\textcopyright} 2020 American Society for Microbiology. All Rights Reserved.",
year = "2020",
month = may,
day = "1",
doi = "10.1128/AAC.02303-19",
language = "English (US)",
volume = "64",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "5",
}