TY - JOUR
T1 - Temperature adaptation of enzymes
T2 - A proposed molecular basis for the different catalytic efficiencies of enzymes from ectotherms and endotherms
AU - Low, Philip S.
AU - Somero, George N.
N1 - Funding Information:
Acknowledgements--This work was supported by National Science Foundation Grant No. GB-31106. We gratefully acknowledge discussions of this work with Drs. John C. Wheeler, Robert Fahey and Jeffrey L. Bada.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1974/10/15
Y1 - 1974/10/15
N2 - 1. 1. A number of enzymic reactions of ectotherms have lower values for the free energy, the enthalpy and the entropy of activation than the homologous reactions of birds and mammals. 2. 2. Differences in the magnitudes of the activation parameters, which lead to marked differences in the catalytic efficiencies of the homologous enzymes, can be accounted for on the basis of increased weak bond formation during the generation of the activated enzyme-substrate complex in ectothermic systems.
AB - 1. 1. A number of enzymic reactions of ectotherms have lower values for the free energy, the enthalpy and the entropy of activation than the homologous reactions of birds and mammals. 2. 2. Differences in the magnitudes of the activation parameters, which lead to marked differences in the catalytic efficiencies of the homologous enzymes, can be accounted for on the basis of increased weak bond formation during the generation of the activated enzyme-substrate complex in ectothermic systems.
KW - activation energy
KW - activation thermodynamics
KW - d-glyceraldehyde-3-phosphate dehydrogenase
KW - glycogen phosphorylase
KW - lactate dehydrogenase
KW - Temperature
KW - temperature adaptation
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U2 - 10.1016/0305-0491(74)90165-5
DO - 10.1016/0305-0491(74)90165-5
M3 - Article
C2 - 4420155
AN - SCOPUS:0016271762
SN - 0305-0491
VL - 49
SP - 307
EP - 312
JO - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
JF - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
IS - 2
ER -