The B Cell Response to Transplantation Antigens

Roger Sciammas; Anita S. Chong; Robert B. Colvin

doi:10.1002/9781444355628.ch4

The B Cell Response to Transplantation Antigens

Roger Sciammas, Anita S. Chong, Robert B. Colvin

Academic Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.

Original language	English (US)
Title of host publication	Immunotherapy in Transplantation
Subtitle of host publication	Principles and Practice
Publisher	Wiley
Pages	38-53
Number of pages	16
ISBN (Print)	9781405182713
DOIs	https://doi.org/10.1002/9781444355628.ch4
State	Published - Apr 19 2012

Keywords

Antibody
B cell
Complement
Plasma cell
Rejection

ASJC Scopus subject areas

Medicine(all)

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10.1002/9781444355628.ch4

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abstract = "Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.",

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AU - Sciammas, Roger

AU - Chong, Anita S.

AU - Colvin, Robert B.

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N2 - Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.

AB - Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.

KW - Antibody

KW - B cell

KW - Complement

KW - Plasma cell

KW - Rejection

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BT - Immunotherapy in Transplantation

PB - Wiley

ER -

The B Cell Response to Transplantation Antigens

Abstract

Keywords

ASJC Scopus subject areas

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