TY - JOUR
T1 - The contextual brain
T2 - Implications for fear conditioning, extinction and psychopathology
AU - Maren, Stephen
AU - Phan, K. Luan
AU - Liberzon, Israel
N1 - Funding Information:
Work from the authors’ laboratories described in this paper is supported by grants from the US National Institutes of Health to S.M. (R01MH065961), K.L.P. (R01MH086517 and R01MH071698) and I.L. (R24MH075999).
PY - 2013/6
Y1 - 2013/6
N2 - Contexts surround and imbue meaning to events; they are essential for recollecting the past, interpreting the present and anticipating the future. Indeed, the brain's capacity to contextualize information permits enormous cognitive and behavioural flexibility. Studies of Pavlovian fear conditioning and extinction in rodents and humans suggest that a neural circuit including the hippocampus, amygdala and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behaviour. Dysfunction in this network may be involved in several forms of psychopathology, including post-traumatic stress disorder, schizophrenia and substance abuse disorders.
AB - Contexts surround and imbue meaning to events; they are essential for recollecting the past, interpreting the present and anticipating the future. Indeed, the brain's capacity to contextualize information permits enormous cognitive and behavioural flexibility. Studies of Pavlovian fear conditioning and extinction in rodents and humans suggest that a neural circuit including the hippocampus, amygdala and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behaviour. Dysfunction in this network may be involved in several forms of psychopathology, including post-traumatic stress disorder, schizophrenia and substance abuse disorders.
UR - http://www.scopus.com/inward/record.url?scp=84878261678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878261678&partnerID=8YFLogxK
U2 - 10.1038/nrn3492
DO - 10.1038/nrn3492
M3 - Review article
C2 - 23635870
AN - SCOPUS:84878261678
SN - 1471-003X
VL - 14
SP - 417
EP - 428
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 6
ER -