The emerging role of the PI3-K-Akt pathway in prostate cancer progression

L. Li; M. M. Ittmann; G. Ayala; M. J. Tsai; R. J. Amato; T. M. Wheeler; Brian J. Miles; D. Kadmon; Timothy C. Thompson

doi:10.1038/sj.pcan.4500776

The emerging role of the PI3-K-Akt pathway in prostate cancer progression

L. Li, M. M. Ittmann, G. Ayala, M. J. Tsai, R. J. Amato, T. M. Wheeler, Brian J. Miles, D. Kadmon, Timothy C. Thompson

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

Abstract

The PI3-K-Akt pathway plays a central role in the development and progression of prostate cancer and other malignancies. We review original studies and summarize relevant sections of previous reviews concerning the relationships between abnormalities in the PI3-K-Akt pathway and prostate cancer progression. We discuss laboratory and clinical data that indicate gene perturbation and dysregulation of PI3-K-Akt pathway is common in prostate cancer and other malignancies. We further discuss the critical role of the PI3-K-Akt pathway in the oncogenic signaling network and provide examples that establish the PI3-K-Akt pathway as a focal point for the future development of informative biomarkers and effective therapies for prostate cancer.

Original language	English (US)
Pages (from-to)	108-118
Number of pages	11
Journal	Prostate Cancer and Prostatic Diseases
Volume	8
Issue number	2
DOIs	https://doi.org/10.1038/sj.pcan.4500776
State	Published - Jun 2005

Keywords

Akt
Biomarker
Caveolin-1
Oncogenic signaling
Prostate cancer
Target
Therapeutic

ASJC Scopus subject areas

Oncology
Urology

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10.1038/sj.pcan.4500776

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title = "The emerging role of the PI3-K-Akt pathway in prostate cancer progression",

abstract = "The PI3-K-Akt pathway plays a central role in the development and progression of prostate cancer and other malignancies. We review original studies and summarize relevant sections of previous reviews concerning the relationships between abnormalities in the PI3-K-Akt pathway and prostate cancer progression. We discuss laboratory and clinical data that indicate gene perturbation and dysregulation of PI3-K-Akt pathway is common in prostate cancer and other malignancies. We further discuss the critical role of the PI3-K-Akt pathway in the oncogenic signaling network and provide examples that establish the PI3-K-Akt pathway as a focal point for the future development of informative biomarkers and effective therapies for prostate cancer.",

keywords = "Akt, Biomarker, Caveolin-1, Oncogenic signaling, Prostate cancer, Target, Therapeutic",

author = "L. Li and Ittmann, {M. M.} and G. Ayala and Tsai, {M. J.} and Amato, {R. J.} and Wheeler, {T. M.} and Miles, {Brian J.} and D. Kadmon and Thompson, {Timothy C.}",

note = "Funding Information: This work was supported by National Cancer Institute Grants CA68814 and SPORE P50-58204.",

year = "2005",

month = jun,

doi = "10.1038/sj.pcan.4500776",

language = "English (US)",

volume = "8",

pages = "108--118",

journal = "Prostate Cancer and Prostatic Diseases",

issn = "1365-7852",

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AU - Li, L.

AU - Ittmann, M. M.

AU - Ayala, G.

AU - Tsai, M. J.

AU - Amato, R. J.

AU - Wheeler, T. M.

AU - Miles, Brian J.

AU - Kadmon, D.

AU - Thompson, Timothy C.

N1 - Funding Information: This work was supported by National Cancer Institute Grants CA68814 and SPORE P50-58204.

PY - 2005/6

Y1 - 2005/6

N2 - The PI3-K-Akt pathway plays a central role in the development and progression of prostate cancer and other malignancies. We review original studies and summarize relevant sections of previous reviews concerning the relationships between abnormalities in the PI3-K-Akt pathway and prostate cancer progression. We discuss laboratory and clinical data that indicate gene perturbation and dysregulation of PI3-K-Akt pathway is common in prostate cancer and other malignancies. We further discuss the critical role of the PI3-K-Akt pathway in the oncogenic signaling network and provide examples that establish the PI3-K-Akt pathway as a focal point for the future development of informative biomarkers and effective therapies for prostate cancer.

AB - The PI3-K-Akt pathway plays a central role in the development and progression of prostate cancer and other malignancies. We review original studies and summarize relevant sections of previous reviews concerning the relationships between abnormalities in the PI3-K-Akt pathway and prostate cancer progression. We discuss laboratory and clinical data that indicate gene perturbation and dysregulation of PI3-K-Akt pathway is common in prostate cancer and other malignancies. We further discuss the critical role of the PI3-K-Akt pathway in the oncogenic signaling network and provide examples that establish the PI3-K-Akt pathway as a focal point for the future development of informative biomarkers and effective therapies for prostate cancer.

KW - Akt

KW - Biomarker

KW - Caveolin-1

KW - Oncogenic signaling

KW - Prostate cancer

KW - Target

KW - Therapeutic

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The emerging role of the PI3-K-Akt pathway in prostate cancer progression

Abstract

Keywords

ASJC Scopus subject areas

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