TY - JOUR
T1 - The evolving role of coronary computed tomography in understanding sex differences in coronary atherosclerosis
AU - Garg, Keva
AU - Patel, Toral R.
AU - Kanwal, Arjun
AU - Villines, Todd C.
AU - Aggarwal, Niti R.
AU - Nasir, Khurram
AU - Blumenthal, Roger S.
AU - Blaha, Michael J.
AU - Douglas, Pamela S.
AU - Shaw, Leslee J.
AU - Sharma, Garima
N1 - Copyright © 2021 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Our understanding of sex differences in subclinical atherosclerosis and plaque composition and characteristics have greatly improved with the use of coronary computed tomography (CCTA) over the past years. CCTA has emerged as an important frontline diagnostic test for women, especially as we continue to understand the impact of non-obstructive atherosclerosis as well as diffuse, high risk plaque as precursors of acute cardiac events in women. Based on its ability to identify complex plaque morphology such as low attenuation plaque, high risk non calcified plaque, positive remodeling, fibrous cap, CCTA can be used to assess plaque characteristics. CCTA can avoid false positive of other imaging studies, if included earlier in assessment of ischemic symptoms. In the contemporary clinical setting, CCTA will prove useful in further understanding and managing cardiovascular disease in women and those without traditional obstructive coronary disease.
AB - Our understanding of sex differences in subclinical atherosclerosis and plaque composition and characteristics have greatly improved with the use of coronary computed tomography (CCTA) over the past years. CCTA has emerged as an important frontline diagnostic test for women, especially as we continue to understand the impact of non-obstructive atherosclerosis as well as diffuse, high risk plaque as precursors of acute cardiac events in women. Based on its ability to identify complex plaque morphology such as low attenuation plaque, high risk non calcified plaque, positive remodeling, fibrous cap, CCTA can be used to assess plaque characteristics. CCTA can avoid false positive of other imaging studies, if included earlier in assessment of ischemic symptoms. In the contemporary clinical setting, CCTA will prove useful in further understanding and managing cardiovascular disease in women and those without traditional obstructive coronary disease.
KW - And cardiac computed tomography
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Ischemic heart disease
KW - Sex
KW - Sex disparities
KW - Women
KW - Predictive Value of Tests
KW - Humans
KW - Male
KW - Tomography, X-Ray Computed
KW - Sex Characteristics
KW - Plaque, Atherosclerotic
KW - Computed Tomography Angiography
KW - Coronary Artery Disease/diagnostic imaging
KW - Female
KW - Coronary Angiography/methods
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UR - http://www.scopus.com/inward/citedby.url?scp=85117147440&partnerID=8YFLogxK
U2 - 10.1016/j.jcct.2021.09.004
DO - 10.1016/j.jcct.2021.09.004
M3 - Review article
C2 - 34654676
AN - SCOPUS:85117147440
SN - 1934-5925
VL - 16
SP - 138
EP - 149
JO - Journal of cardiovascular computed tomography
JF - Journal of cardiovascular computed tomography
IS - 2
ER -