TY - JOUR
T1 - The First Case of Ischemia-Free Kidney Transplantation in Humans
AU - He, Xiaoshun
AU - Chen, Guodong
AU - Zhu, Zebin
AU - Zhang, Zhiheng
AU - Yuan, Xiaopeng
AU - Han, Ming
AU - Zhao, Qiang
AU - Zheng, Yitao
AU - Tang, Yunhua
AU - Huang, Shanzhou
AU - Wang, Linhe
AU - van Leeuwen, Otto B.
AU - Wang, Xiaoping
AU - Chen, Chuanbao
AU - Mo, Liqiu
AU - Jiao, Xingyuan
AU - Li, Xianchang
AU - Wang, Changxi
AU - Huang, Jiefu
AU - Cui, Jun
AU - Guo, Zhiyong
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (81373156, 81471583, 81570587, and 81871257), the Special Fund for Science Research by Ministry of Health (201302009), the Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People’s Republic of China, the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007), Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation) (2015B050501002), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project (2015A030308010 and 2018A030313612), Guangdong Provincial Natural Science Funds for Distinguished Young Scholars (2015A030306025), the Special Support Program for Training High-Level Talents in Guangdong Province (2015TQ01R168), the Pearl River Nova Program of Guangzhou (201506010014), and the Science and Technology Program of Guangzhou (201704020150).
Funding Information:
We thank all members of the organ procurement organization, surgical intensive care unit, transplant anesthesia team, and cardiopulmonary bypass team, as well as all the donors and patients. Funding. This study was supported by the National Natural Science Foundation of China (81373156, 81471583, 81570587, and 81871257), the Special Fund for Science Research by Ministry of Health (201302009), the Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People's Republic of China, the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007), Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation) (2015B050501002), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project (2015A030308010 and 2018A030313612), Guangdong Provincial Natural Science Funds for Distinguished Young Scholars (2015A030306025), the Special Support Program for Training High-Level Talents in Guangdong Province (2015TQ01R168), the Pearl River Nova Program of Guangzhou (201506010014), and the Science and Technology Program of Guangzhou (201704020150).
Publisher Copyright:
© Copyright © 2019 He, Chen, Zhu, Zhang, Yuan, Han, Zhao, Zheng, Tang, Huang, Wang, van Leeuwen, Wang, Chen, Mo, Jiao, Li, Wang, Huang, Cui and Guo.
PY - 2019/12/11
Y1 - 2019/12/11
N2 - Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.
AB - Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.
KW - ischemia-free kidney transplantation
KW - ischemia-free organ transplantation
KW - ischemia-reperfusion injury
KW - kidney transplantation
KW - normothermic machine perfusion
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U2 - 10.3389/fmed.2019.00276
DO - 10.3389/fmed.2019.00276
M3 - Article
AN - SCOPUS:85077334938
SN - 2296-858X
VL - 6
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 276
ER -