The function of BAFF on T helper cells in autoimmunity

Maogen Chen; Xiaohong Lin; Ya Liu; Qiang Li; Yiling Deng; Zhongmin Liu; David Brand; Zhiyong Guo; Xiaoshun He; Bernhard Ryffel; Song Guo Zheng

doi:10.1016/j.cytogfr.2013.12.011

The function of BAFF on T helper cells in autoimmunity

Maogen Chen, Xiaohong Lin, Ya Liu, Qiang Li, Yiling Deng, Zhongmin Liu, David Brand, Zhiyong Guo, Xiaoshun He, Bernhard Ryffel, Song Guo Zheng

Research output: Contribution to journal › Short survey › peer-review

61 Scopus citations

Abstract

B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.

Original language	English (US)
Pages (from-to)	301-305
Number of pages	5
Journal	Cytokine and Growth Factor Reviews
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.cytogfr.2013.12.011
State	Published - Jun 2014

Keywords

BAFF
T helper cells
Tfh cells
Th17
Treg cells

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/j.cytogfr.2013.12.011

Cite this

@article{6cf96e632e454251aba97dfb827bca01,

title = "The function of BAFF on T helper cells in autoimmunity",

abstract = "B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.",

keywords = "BAFF, T helper cells, Tfh cells, Th17, Treg cells",

author = "Maogen Chen and Xiaohong Lin and Ya Liu and Qiang Li and Yiling Deng and Zhongmin Liu and David Brand and Zhiyong Guo and Xiaoshun He and Bernhard Ryffel and Zheng, {Song Guo}",

note = "Funding Information: This work was supported in part by grants from the NIH ( AR059103 and AI084359 ), ACR Within Our Reach Fund , Arthritis Foundation and Wright Foundation , National Natural Science Foundation of China (No. 81373156 ); Science and Technology Planning Project of Guangdong Province, China (No. 2010B031600200 ). ",

year = "2014",

month = jun,

doi = "10.1016/j.cytogfr.2013.12.011",

language = "English (US)",

volume = "25",

pages = "301--305",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - The function of BAFF on T helper cells in autoimmunity

AU - Chen, Maogen

AU - Lin, Xiaohong

AU - Liu, Ya

AU - Li, Qiang

AU - Deng, Yiling

AU - Liu, Zhongmin

AU - Brand, David

AU - Guo, Zhiyong

AU - He, Xiaoshun

AU - Ryffel, Bernhard

AU - Zheng, Song Guo

N1 - Funding Information: This work was supported in part by grants from the NIH ( AR059103 and AI084359 ), ACR Within Our Reach Fund , Arthritis Foundation and Wright Foundation , National Natural Science Foundation of China (No. 81373156 ); Science and Technology Planning Project of Guangdong Province, China (No. 2010B031600200 ).

PY - 2014/6

Y1 - 2014/6

N2 - B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.

AB - B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.

KW - BAFF

KW - T helper cells

KW - Tfh cells

KW - Th17

KW - Treg cells

UR - http://www.scopus.com/inward/record.url?scp=84902118801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902118801&partnerID=8YFLogxK

U2 - 10.1016/j.cytogfr.2013.12.011

DO - 10.1016/j.cytogfr.2013.12.011

M3 - Short survey

C2 - 24411564

AN - SCOPUS:84902118801

SN - 1359-6101

VL - 25

SP - 301

EP - 305

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 3

ER -

The function of BAFF on T helper cells in autoimmunity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this