TY - JOUR
T1 - The Global Burden of Early-Onset Biliary Tract Cancer
T2 - Insight From the Global Burden of Disease Study 2019
AU - Danpanichkul, Pojsakorn
AU - Ng, Cheng H.
AU - Tan, Darren J.H.
AU - Muthiah, Mark D.
AU - Kongarin, Siwanart
AU - Srisurapanont, Karan
AU - Kanjanakot, Yatawee
AU - Duangsonk, Kwanjit
AU - Huang, Daniel Q.
AU - Suzuki, Hiroyuki
AU - Harnois, Denise M.
AU - Yang, Ju D.
AU - Noureddin, Mazen
AU - Wijarnpreecha, Karn
N1 - Funding Information:
The figures of world maps were created by using mapchart.net.
Publisher Copyright:
© 2023 Indian National Association for Study of the Liver
PY - 2024/3/1
Y1 - 2024/3/1
N2 - Backgrounds/objectives: The escalating incidence of early-onset gastrointestinal cancers is becoming a primary global health concern. Biliary tract cancer (BTC) has been relatively understudied in this regard. We conducted an epidemiological study regarding the burden of this condition. Methods: We utilized data from the Global Burden of Disease Study 2019 to investigate the temporal trends in early-onset BTC (EOBTC), encompassing the estimation of frequencies and age-standardized rates (ASRs) of EOBTC incidence, mortality, and disability-adjusted life-years (DALYs), from 2010 to 2019. Results: EOBTC constituted nearly 7%of all BTC cases worldwide. The incidence rates of EOBTC decreased significantly in most regions, except in the Eastern Mediterranean (annual percentage change +1.04 %), where the incidence is rising. Stratified by the sociodemographic index (SDI), countries with low middle SDI (annual percentage change +0.5 %) show increasing incidence of EOBTC. The ASR of death and DALYs decreased in most regions. The ASR of EOBTC-related death and disability attributable to high body mass index increased in most regions, with the highest increase in Southeast Asia and low, middle SDI strata. Conclusions: There was a reduction in the burden of EOBTC globally, except for Eastern Mediterranean countries and low-middle SDI countries.
AB - Backgrounds/objectives: The escalating incidence of early-onset gastrointestinal cancers is becoming a primary global health concern. Biliary tract cancer (BTC) has been relatively understudied in this regard. We conducted an epidemiological study regarding the burden of this condition. Methods: We utilized data from the Global Burden of Disease Study 2019 to investigate the temporal trends in early-onset BTC (EOBTC), encompassing the estimation of frequencies and age-standardized rates (ASRs) of EOBTC incidence, mortality, and disability-adjusted life-years (DALYs), from 2010 to 2019. Results: EOBTC constituted nearly 7%of all BTC cases worldwide. The incidence rates of EOBTC decreased significantly in most regions, except in the Eastern Mediterranean (annual percentage change +1.04 %), where the incidence is rising. Stratified by the sociodemographic index (SDI), countries with low middle SDI (annual percentage change +0.5 %) show increasing incidence of EOBTC. The ASR of death and DALYs decreased in most regions. The ASR of EOBTC-related death and disability attributable to high body mass index increased in most regions, with the highest increase in Southeast Asia and low, middle SDI strata. Conclusions: There was a reduction in the burden of EOBTC globally, except for Eastern Mediterranean countries and low-middle SDI countries.
KW - biliary tract cancer
KW - cholangiocarcinoma
KW - early-onset cancer
KW - gallbladder cancer
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U2 - 10.1016/j.jceh.2023.101320
DO - 10.1016/j.jceh.2023.101320
M3 - Article
C2 - 38261906
AN - SCOPUS:85181805150
SN - 0973-6883
VL - 14
SP - 101320
JO - Journal of Clinical and Experimental Hepatology
JF - Journal of Clinical and Experimental Hepatology
IS - 2
M1 - 101320
ER -