@article{ed936571b98046d6968dd59e6985da4f,
title = "The impact of early life stress and immune challenge on behavior and glia cells alteration in late adolescent rats",
abstract = "Maternal deprivation (MD) is known to be related to long-term changes that could influence the onset of psychiatric disorders. Studies have demonstrated that early life stress makes the cells in the brain more susceptible to subsequent stressors. To test it, we used an animal model of MD conducted from postnatal day (PND) 1 to 10. Deprived and non-deprived rats (control) were randomized to receive or not lipopolysaccharide (LPS) at 5 mg/kg on PND 50. The behavior and glial cells activation were evaluated in all groups from 51 to 53 PND. There was an increase in the immobility time in the MD and MD+LPS groups. The spontaneous locomotor activity was not changed between groups. We found elevated ionized calcium-binding adapter molecule 1 (Iba-1)-positive cells levels in the control+LPS and MD+LPS groups. In the MD+LPS group, it was found an increase in Iba-positive cells compared to the MD+sal group. The glial fibrillary acidic protein (GFAP)-positive cells were also increased in the MD+LPS, compared to control+sal, control+LPS, and MD+sal groups. Immune challenge by LPS in late adolescence, which was subjected to MD, did not influence the depressive-like behavior but exerted a pronounced effect in the microglial activation and astrocyte atrophy.",
keywords = "animal model of depression, astrocyte, lipopolysaccharide, major depressive disorder, maternal deprivation, microglia",
author = "R{\'e}us, {Gislaine Z.} and Giridharan, {Vijayasree V.} and {de Moura}, {Airam B.} and Borba, {Laura A.} and Botelho, {Maria Eduarda M.} and Behenck, {Jo{\~a}o Paulo} and Generoso, {Jaqueline S.} and Sudhakar Selvaraj and Gursimrat Bhatti and Tatiana Barichello and Jo{\~a}o Quevedo",
note = "Funding Information: The Translational Psychiatry Program (USA) is funded by the Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth). The Center of Excellence on Mood Disorders (USA) is funded by the Pat Rutherford Jr. Chair in Psychiatry, John S. Dunn Foundation, and Anne and Don Fizer Foundation Endowment for Depression Research. Translational Psychiatry Laboratory is supported by grants from CNPq (JQ and GZR), FAPESC (JQ and GZR), CAPES (GZR and JQ), Instituto C{\'e}rebro e Mente (JQ and GZR), and UNESC (JQ and GZR). JQ is a 1A and GZR is a 2 CNPq Researches Fellow. ABM is a CAPES Research Fellow. Funding Information: The Translational Psychiatry Program (USA) is funded by the Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth). The Center of Excellence on Mood Disorders (USA) is funded by the Pat Rutherford Jr. Chair in Psychiatry, John S. Dunn Foundation, and Anne and Don Fizer Foundation Endowment for Depression Research. Translational Psychiatry Laboratory is supported by grants from CNPq (JQ and GZR), FAPESC (JQ and GZR), CAPES (GZR and JQ), Instituto C?rebro e Mente (JQ and GZR), and UNESC (JQ and GZR). JQ is a 1A and GZR is a 2 CNPq Researches Fellow. ABM is a CAPES Research Fellow. Publisher Copyright: {\textcopyright} 2021 International Society for Developmental Neuroscience. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = aug,
doi = "10.1002/jdn.10108",
language = "English (US)",
volume = "81",
pages = "407--415",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Elsevier Limited",
number = "5",
}