The medullary cerebrovascular vasodilator area mediates cerebrovascular vasodilation and electroencephalogram synchronization elicited from cerebellar fastigial nucleus in Sprague-Dawley rats

Eugene V. Golanov; John R.C. Christensen; Donald J. Reis

doi:10.1016/S0304-3940(00)01228-3

The medullary cerebrovascular vasodilator area mediates cerebrovascular vasodilation and electroencephalogram synchronization elicited from cerebellar fastigial nucleus in Sprague-Dawley rats

Eugene V. Golanov, John R.C. Christensen, Donald J. Reis

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We investigated whether the medullary cerebrovasodilator area (MCVA), a region of ventral medulla mediating elevations of regional cerebral blood flow (rCBF) and electroencephalogram (EEG) synchronization elicited in cerebral cortex from stimulation of reticulospinal neurons of rostral ventrolateral medulla (RVLM), also mediates comparable responses from the cerebellar fastigial nucleus (FN). In spinalized rats, electrical stimulation of MCVA, RVLM or FN elevated rCBF and synchronized the EEG. The FN-evoked responses were significantly attenuated or blocked by bilateral lesions of MCVA. The MCVA is a novel region of medullary reticular formation mediating actions of medullary and cerebellar centers on rCBF and EEG to link visceral centers of brainstem and cerebral cortex. Copyright (C) 2000.

Original language	English (US)
Pages (from-to)	183-186
Number of pages	4
Journal	Neuroscience Letters
Volume	288
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(00)01228-3
State	Published - Jul 21 2000

Keywords

Cerebellum
Cerebral blood flow
Fastigial nucleus
Medulla oblongata
Medullary cerebrovasodilator area
Rostral ventrolateral medulla

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(00)01228-3

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The medullary cerebrovascular vasodilator area mediates cerebrovascular vasodilation and electroencephalogram synchronization elicited from cerebellar fastigial nucleus in Sprague-Dawley rats. / Golanov, Eugene V.; Christensen, John R.C.; Reis, Donald J.
In: Neuroscience Letters, Vol. 288, No. 3, 21.07.2000, p. 183-186.

Research output: Contribution to journal › Article › peer-review

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title = "The medullary cerebrovascular vasodilator area mediates cerebrovascular vasodilation and electroencephalogram synchronization elicited from cerebellar fastigial nucleus in Sprague-Dawley rats",

abstract = "We investigated whether the medullary cerebrovasodilator area (MCVA), a region of ventral medulla mediating elevations of regional cerebral blood flow (rCBF) and electroencephalogram (EEG) synchronization elicited in cerebral cortex from stimulation of reticulospinal neurons of rostral ventrolateral medulla (RVLM), also mediates comparable responses from the cerebellar fastigial nucleus (FN). In spinalized rats, electrical stimulation of MCVA, RVLM or FN elevated rCBF and synchronized the EEG. The FN-evoked responses were significantly attenuated or blocked by bilateral lesions of MCVA. The MCVA is a novel region of medullary reticular formation mediating actions of medullary and cerebellar centers on rCBF and EEG to link visceral centers of brainstem and cerebral cortex. Copyright (C) 2000.",

keywords = "Cerebellum, Cerebral blood flow, Fastigial nucleus, Medulla oblongata, Medullary cerebrovasodilator area, Rostral ventrolateral medulla",

author = "Golanov, {Eugene V.} and Christensen, {John R.C.} and Reis, {Donald J.}",

note = "Funding Information: Supported by NIH Grants NS36154 (EVG) and HL 18974 (DJR and EVG), and the Irving Harris Foundation.",

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AU - Golanov, Eugene V.

AU - Christensen, John R.C.

AU - Reis, Donald J.

N1 - Funding Information: Supported by NIH Grants NS36154 (EVG) and HL 18974 (DJR and EVG), and the Irving Harris Foundation.

PY - 2000/7/21

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N2 - We investigated whether the medullary cerebrovasodilator area (MCVA), a region of ventral medulla mediating elevations of regional cerebral blood flow (rCBF) and electroencephalogram (EEG) synchronization elicited in cerebral cortex from stimulation of reticulospinal neurons of rostral ventrolateral medulla (RVLM), also mediates comparable responses from the cerebellar fastigial nucleus (FN). In spinalized rats, electrical stimulation of MCVA, RVLM or FN elevated rCBF and synchronized the EEG. The FN-evoked responses were significantly attenuated or blocked by bilateral lesions of MCVA. The MCVA is a novel region of medullary reticular formation mediating actions of medullary and cerebellar centers on rCBF and EEG to link visceral centers of brainstem and cerebral cortex. Copyright (C) 2000.

AB - We investigated whether the medullary cerebrovasodilator area (MCVA), a region of ventral medulla mediating elevations of regional cerebral blood flow (rCBF) and electroencephalogram (EEG) synchronization elicited in cerebral cortex from stimulation of reticulospinal neurons of rostral ventrolateral medulla (RVLM), also mediates comparable responses from the cerebellar fastigial nucleus (FN). In spinalized rats, electrical stimulation of MCVA, RVLM or FN elevated rCBF and synchronized the EEG. The FN-evoked responses were significantly attenuated or blocked by bilateral lesions of MCVA. The MCVA is a novel region of medullary reticular formation mediating actions of medullary and cerebellar centers on rCBF and EEG to link visceral centers of brainstem and cerebral cortex. Copyright (C) 2000.

KW - Cerebellum

KW - Cerebral blood flow

KW - Fastigial nucleus

KW - Medulla oblongata

KW - Medullary cerebrovasodilator area

KW - Rostral ventrolateral medulla

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ER -

The medullary cerebrovascular vasodilator area mediates cerebrovascular vasodilation and electroencephalogram synchronization elicited from cerebellar fastigial nucleus in Sprague-Dawley rats

Abstract

Keywords

ASJC Scopus subject areas

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