The nucleolus and viral infection

Lei Wang; Xiao Ming Ren; Jun Ji Xing; Alan C. Zheng

doi:10.1007/s12250-010-3093-5

The nucleolus and viral infection

Lei Wang, Xiao Ming Ren, Jun Ji Xing, Alan C. Zheng

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.

Original language	English (US)
Pages (from-to)	151-157
Number of pages	7
Journal	Virologica Sinica
Volume	25
Issue number	3
DOIs	https://doi.org/10.1007/s12250-010-3093-5
State	Published - Jun 2010

Keywords

Cell cycle regulation
Nucleolus
Stress
Virus infection

ASJC Scopus subject areas

Immunology
Molecular Medicine
Virology

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10.1007/s12250-010-3093-5

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title = "The nucleolus and viral infection",

abstract = "The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.",

keywords = "Cell cycle regulation, Nucleolus, Stress, Virus infection",

author = "Lei Wang and Ren, {Xiao Ming} and Xing, {Jun Ji} and Zheng, {Alan C.}",

note = "Funding Information: Received: 2009-09-21, Accepted:2010-03-31 * Foundation items: The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science (2007 1010141); National Natural Science Foundation of China (30870120); Open Research Fund Program of the State Key Laboratory of Virology of China (2007003, 2009007); Hubei Province Natural Science Foundation of Innovation Groups Project (2008CDA013). # These authors contributed equally to this work. ** Corresponding author. Phone: +86-27-87198676, E-mail: zhengcf@wh.iov.cn",

year = "2010",

month = jun,

doi = "10.1007/s12250-010-3093-5",

language = "English (US)",

volume = "25",

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T1 - The nucleolus and viral infection

AU - Wang, Lei

AU - Ren, Xiao Ming

AU - Xing, Jun Ji

AU - Zheng, Alan C.

N1 - Funding Information: Received: 2009-09-21, Accepted:2010-03-31 * Foundation items: The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science (2007 1010141); National Natural Science Foundation of China (30870120); Open Research Fund Program of the State Key Laboratory of Virology of China (2007003, 2009007); Hubei Province Natural Science Foundation of Innovation Groups Project (2008CDA013). # These authors contributed equally to this work. ** Corresponding author. Phone: +86-27-87198676, E-mail: zhengcf@wh.iov.cn

PY - 2010/6

Y1 - 2010/6

N2 - The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.

AB - The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.

KW - Cell cycle regulation

KW - Nucleolus

KW - Stress

KW - Virus infection

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U2 - 10.1007/s12250-010-3093-5

DO - 10.1007/s12250-010-3093-5

M3 - Review article

C2 - 20960288

AN - SCOPUS:77953320943

SN - 1674-0769

VL - 25

SP - 151

EP - 157

JO - Virologica Sinica

JF - Virologica Sinica

IS - 3

ER -

The nucleolus and viral infection

Abstract

Keywords

ASJC Scopus subject areas

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