TY - JOUR
T1 - The Olympicenyl Radical and Its Derivatives
AU - Xiang, Qin
AU - Ye, Lei
AU - Ma, Lan
AU - Sun, Zhe
N1 - Funding Information:
We acknowledge financial support from National Natural Science Foundation of China (Grant No. 21971187, 22222110, 22371206, 22201206), Natural Science Foundation of Tianjin (19JCJQJC62700), the China Postdoctoral Science Foundation (2022 M722358) and the Haihe Laboratory of Sustainable Chemical Transformations.
Publisher Copyright:
© 2023 Wiley-VCH GmbH.
PY - 2023
Y1 - 2023
N2 - The olympicenyl radical (OR) has long been a fascinating spin doublet hydrocarbon radical that evoked theoretical and experimental research interests, but the chemistry of olympicenyl was limited by its inherent instability. Recently, this field was revived by the advent of stable, multi-substituted ORs and the isolation of them in the crystalline phase. In this minireview, we summarize the early studies on the pristine OR, as well as the recent advances on the substituted OR derivatives, heteroatom-containing OR derivatives, and OR-based diradicals and polyradicals. The synthetic chemistry, stabilization strategies, self-association behaviors, reactivities, and applications in the biological field of the abovementioned compounds were discussed.
AB - The olympicenyl radical (OR) has long been a fascinating spin doublet hydrocarbon radical that evoked theoretical and experimental research interests, but the chemistry of olympicenyl was limited by its inherent instability. Recently, this field was revived by the advent of stable, multi-substituted ORs and the isolation of them in the crystalline phase. In this minireview, we summarize the early studies on the pristine OR, as well as the recent advances on the substituted OR derivatives, heteroatom-containing OR derivatives, and OR-based diradicals and polyradicals. The synthetic chemistry, stabilization strategies, self-association behaviors, reactivities, and applications in the biological field of the abovementioned compounds were discussed.
KW - biomedical applications
KW - dimerization
KW - heterocycles
KW - polycyclic aromatic hydrocarbons
KW - radicals •
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U2 - 10.1002/cplu.202300571
DO - 10.1002/cplu.202300571
M3 - Review article
AN - SCOPUS:85178149562
SN - 2192-6506
JO - ChemPlusChem
JF - ChemPlusChem
ER -