The role of mTOR signalling pathway in hypoxia-induced cognitive impairment

Entesar Yaseen Abdo Qaid; Ninie Nadia Zulkipli; Rahimah Zakaria; Asma Hayati Ahmad; Zahiruddin Othman; Sangu Muthuraju; Teguh Haryo Sasongko

doi:10.1080/00207454.2020.1746308

The role of mTOR signalling pathway in hypoxia-induced cognitive impairment

Entesar Yaseen Abdo Qaid, Ninie Nadia Zulkipli, Rahimah Zakaria, Asma Hayati Ahmad, Zahiruddin Othman, Sangu Muthuraju, Teguh Haryo Sasongko

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Hypoxia has been associated with cognitive impairment. Many studies have investigated the role of mTOR signalling pathway in cognitive functions but its role in hypoxia-induced cognitive impairment remains controversial. This review aimed to elucidate the role of mTOR in the mechanisms of cognitive impairment that may pave the way towards the mechanistic understanding and therapeutic intervention of hypoxia-induced cognitive impairment. mTORC1 is normally regulated during mild or acute hypoxic exposure giving rise to neuroprotection, whereas it is overactivated during severe or chronic hypoxia giving rise to neuronal cells death. Thus, it is worth exploring the possibility of maintaining normal mTORC1 activity and thereby preventing cognitive impairment during severe or chronic hypoxia.

Original language	English (US)
Pages (from-to)	482-488
Number of pages	7
Journal	International Journal of Neuroscience
Volume	131
Issue number	5
DOIs	https://doi.org/10.1080/00207454.2020.1746308
State	Published - 2021

Keywords

BDNF
cognitive impairment
HIF-1
Hypoxia
mTORC1
mTORC2

ASJC Scopus subject areas

Neuroscience(all)

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10.1080/00207454.2020.1746308

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title = "The role of mTOR signalling pathway in hypoxia-induced cognitive impairment",

abstract = "Hypoxia has been associated with cognitive impairment. Many studies have investigated the role of mTOR signalling pathway in cognitive functions but its role in hypoxia-induced cognitive impairment remains controversial. This review aimed to elucidate the role of mTOR in the mechanisms of cognitive impairment that may pave the way towards the mechanistic understanding and therapeutic intervention of hypoxia-induced cognitive impairment. mTORC1 is normally regulated during mild or acute hypoxic exposure giving rise to neuroprotection, whereas it is overactivated during severe or chronic hypoxia giving rise to neuronal cells death. Thus, it is worth exploring the possibility of maintaining normal mTORC1 activity and thereby preventing cognitive impairment during severe or chronic hypoxia.",

keywords = "BDNF, cognitive impairment, HIF-1, Hypoxia, mTORC1, mTORC2",

author = "{Abdo Qaid}, {Entesar Yaseen} and Zulkipli, {Ninie Nadia} and Rahimah Zakaria and Ahmad, {Asma Hayati} and Zahiruddin Othman and Sangu Muthuraju and Sasongko, {Teguh Haryo}",

note = "Funding Information: This research work was supported by Short-term grant of Universiti Sains Malaysia; 304/PPSP/61313086. Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

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doi = "10.1080/00207454.2020.1746308",

language = "English (US)",

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AU - Abdo Qaid, Entesar Yaseen

AU - Zulkipli, Ninie Nadia

AU - Zakaria, Rahimah

AU - Ahmad, Asma Hayati

AU - Othman, Zahiruddin

AU - Muthuraju, Sangu

AU - Sasongko, Teguh Haryo

N1 - Funding Information: This research work was supported by Short-term grant of Universiti Sains Malaysia; 304/PPSP/61313086. Publisher Copyright: © 2020 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2021

Y1 - 2021

N2 - Hypoxia has been associated with cognitive impairment. Many studies have investigated the role of mTOR signalling pathway in cognitive functions but its role in hypoxia-induced cognitive impairment remains controversial. This review aimed to elucidate the role of mTOR in the mechanisms of cognitive impairment that may pave the way towards the mechanistic understanding and therapeutic intervention of hypoxia-induced cognitive impairment. mTORC1 is normally regulated during mild or acute hypoxic exposure giving rise to neuroprotection, whereas it is overactivated during severe or chronic hypoxia giving rise to neuronal cells death. Thus, it is worth exploring the possibility of maintaining normal mTORC1 activity and thereby preventing cognitive impairment during severe or chronic hypoxia.

AB - Hypoxia has been associated with cognitive impairment. Many studies have investigated the role of mTOR signalling pathway in cognitive functions but its role in hypoxia-induced cognitive impairment remains controversial. This review aimed to elucidate the role of mTOR in the mechanisms of cognitive impairment that may pave the way towards the mechanistic understanding and therapeutic intervention of hypoxia-induced cognitive impairment. mTORC1 is normally regulated during mild or acute hypoxic exposure giving rise to neuroprotection, whereas it is overactivated during severe or chronic hypoxia giving rise to neuronal cells death. Thus, it is worth exploring the possibility of maintaining normal mTORC1 activity and thereby preventing cognitive impairment during severe or chronic hypoxia.

KW - BDNF

KW - cognitive impairment

KW - HIF-1

KW - Hypoxia

KW - mTORC1

KW - mTORC2

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The role of mTOR signalling pathway in hypoxia-induced cognitive impairment

Abstract

Keywords

ASJC Scopus subject areas

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