TY - JOUR
T1 - Thyroid dermopathy responds to teprotumumab therapy
AU - Crespo-Trevino, Ricaurte
AU - Schiffman, Jade
AU - Ugradar, Shoaib
AU - Cockerham, Kimberly
AU - Douglas, Raymond
AU - de Leon-Garza, David
AU - Tang, Rosa
N1 - Funding Information:
R D – Consultant Horizon Therapeutics, Immunovant Corporation, Veridian Corporation; K C – Consultant Horizon Therapeutics, Viridian Pharmaceuticals and 3T Ophthalmics; J S, R D, and R T – involved in clinical trials funded by Horizon; J S and R T - advisory board for Horizon; R C and
Publisher Copyright:
© 2022 The authors.
PY - 2022
Y1 - 2022
N2 - SUMMARY: Thyroid dermopathy is an uncommon manifestation of thyroid disease that impairs the quality of life in certain cases. Currently, the available treatments offer limited results and a chance of recurrence. Teprotumumab, a novel medication that results in the regression of thyroid ophthalmopathy, may have similar effects on dermopathy. We describe four patients treated with teprotumumab for their thyroid ophthalmopathy who concomitantly had dermatopathy upon initiation of their infusions. Patients improved after two to three infusions and three out of the four patients have not suffered a recurrence.Teprotumumab is a monoclonal antibody (MAB) that attenuates an inflammatory response, resulting in decreased edema and tissue expansion. Given the similarities of their pathophysiology, we believe that the resolution of thyroid dermatopathy and regression of thyroid eye disease occurs via the same mechanism. We encourage further investigation utilizing teprotumumab for patients whose dermopathy is associated with impaired quality of life.LEARNING POINTS: Thyroid dermopathy (TD), an uncommon manifestation of thyroid disease, may occasionally impair function and quality of life. There are only a few treatments for TD, with limited results and high rates of recurrence. Teprotumumab is a Food and Drug Administration-approved medication used for thyroid eye disease (TED). Our patients treated with teprotumumab for TED showed improvement of TD, which demonstrates its potential use for this condition.
AB - SUMMARY: Thyroid dermopathy is an uncommon manifestation of thyroid disease that impairs the quality of life in certain cases. Currently, the available treatments offer limited results and a chance of recurrence. Teprotumumab, a novel medication that results in the regression of thyroid ophthalmopathy, may have similar effects on dermopathy. We describe four patients treated with teprotumumab for their thyroid ophthalmopathy who concomitantly had dermatopathy upon initiation of their infusions. Patients improved after two to three infusions and three out of the four patients have not suffered a recurrence.Teprotumumab is a monoclonal antibody (MAB) that attenuates an inflammatory response, resulting in decreased edema and tissue expansion. Given the similarities of their pathophysiology, we believe that the resolution of thyroid dermatopathy and regression of thyroid eye disease occurs via the same mechanism. We encourage further investigation utilizing teprotumumab for patients whose dermopathy is associated with impaired quality of life.LEARNING POINTS: Thyroid dermopathy (TD), an uncommon manifestation of thyroid disease, may occasionally impair function and quality of life. There are only a few treatments for TD, with limited results and high rates of recurrence. Teprotumumab is a Food and Drug Administration-approved medication used for thyroid eye disease (TED). Our patients treated with teprotumumab for TED showed improvement of TD, which demonstrates its potential use for this condition.
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U2 - 10.1530/EDM-21-0201
DO - 10.1530/EDM-21-0201
M3 - Article
C2 - 35319490
AN - SCOPUS:85128989554
SN - 2052-0573
VL - 2022
JO - Endocrinology, Diabetes and Metabolism Case Reports
JF - Endocrinology, Diabetes and Metabolism Case Reports
IS - 1
M1 - 21-0201
ER -