TRACE METALS AND DEGENERATIVE DISEASES OF THE SKELETON

J. Savory; R. L. Bertholf; M. R. Wills

doi:10.1111/j.1600-0773.1986.tb02764.x

TRACE METALS AND DEGENERATIVE DISEASES OF THE SKELETON

J. Savory, R. L. Bertholf, M. R. Wills

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Abstract Aluminum related osteodystrophy is the most important manifestion of trace metal toxicity related to degenerative diseases of the skeleton. Aluminum overload occurs in chronic renal failure patients on hemodialysis treatment and results from transfer from dialysis solutions and from oral intake of aluminum containing phosphate binding gels. Laboratory diagnosis involves serum and bone analysis and bone staining for aluminum. A challenge test with desferoxamine also aids in the diagnosis. Electrothermal atomic absorption spectrometry is widely used for aluminum detection. Guidelines for toxic concentrations of aluminum have been established. 1986 Nordic Pharmacological Society

Original language	English (US)
Pages (from-to)	282-288
Number of pages	7
Journal	Acta Pharmacologica et Toxicologica
Volume	59
DOIs	https://doi.org/10.1111/j.1600-0773.1986.tb02764.x
State	Published - Dec 1986

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1111/j.1600-0773.1986.tb02764.x

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abstract = "Abstract Aluminum related osteodystrophy is the most important manifestion of trace metal toxicity related to degenerative diseases of the skeleton. Aluminum overload occurs in chronic renal failure patients on hemodialysis treatment and results from transfer from dialysis solutions and from oral intake of aluminum containing phosphate binding gels. Laboratory diagnosis involves serum and bone analysis and bone staining for aluminum. A challenge test with desferoxamine also aids in the diagnosis. Electrothermal atomic absorption spectrometry is widely used for aluminum detection. Guidelines for toxic concentrations of aluminum have been established. 1986 Nordic Pharmacological Society",

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AU - Wills, M. R.

PY - 1986/12

Y1 - 1986/12

N2 - Abstract Aluminum related osteodystrophy is the most important manifestion of trace metal toxicity related to degenerative diseases of the skeleton. Aluminum overload occurs in chronic renal failure patients on hemodialysis treatment and results from transfer from dialysis solutions and from oral intake of aluminum containing phosphate binding gels. Laboratory diagnosis involves serum and bone analysis and bone staining for aluminum. A challenge test with desferoxamine also aids in the diagnosis. Electrothermal atomic absorption spectrometry is widely used for aluminum detection. Guidelines for toxic concentrations of aluminum have been established. 1986 Nordic Pharmacological Society

AB - Abstract Aluminum related osteodystrophy is the most important manifestion of trace metal toxicity related to degenerative diseases of the skeleton. Aluminum overload occurs in chronic renal failure patients on hemodialysis treatment and results from transfer from dialysis solutions and from oral intake of aluminum containing phosphate binding gels. Laboratory diagnosis involves serum and bone analysis and bone staining for aluminum. A challenge test with desferoxamine also aids in the diagnosis. Electrothermal atomic absorption spectrometry is widely used for aluminum detection. Guidelines for toxic concentrations of aluminum have been established. 1986 Nordic Pharmacological Society

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TRACE METALS AND DEGENERATIVE DISEASES OF THE SKELETON

Abstract

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