TY - JOUR
T1 - Tracking biodistribution of myeloid-derived cells in murine models of breast cancer
AU - Li, Jun
AU - Mai, Junhua
AU - Hinkle, Louis
AU - Lin, Daniel
AU - Zhang, Jingxin
AU - Liu, Xiaoling
AU - Ramirez, Maricela R.
AU - Zu, Youli
AU - Lokesh, Ganesh L.
AU - Volk, David E.
AU - Shen, Haifa
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/4
Y1 - 2019/4
N2 - A growing tumor is constantly secreting inflammatory chemokines and cytokines that induce release of immature myeloid cells, including myeloid-derived suppressor cells (MDSCs) and macrophages, from the bone marrow. These cells not only promote tumor growth, but also prepare distant organs for tumor metastasis. On the other hand, the myeloid-derived cells also have phagocytic potential, and can serve as vehicles for drug delivery. We have previously identified thioaptamers that bind a subset of MDSCs with high a_nity and specificity. In the current study, we applied one of the thioaptamers as a probe to track myeloid cell distribution in the bone, liver, spleen and tumor in multiple murine models of breast cancer including the 4T1 syngeneic model and MDA-MB-231 and SUM159 xenograft models. Information generated from this study will facilitate further understanding of tumor growth and metastasis, and predict biodistribution patterns of cell-mediated drug delivery.
AB - A growing tumor is constantly secreting inflammatory chemokines and cytokines that induce release of immature myeloid cells, including myeloid-derived suppressor cells (MDSCs) and macrophages, from the bone marrow. These cells not only promote tumor growth, but also prepare distant organs for tumor metastasis. On the other hand, the myeloid-derived cells also have phagocytic potential, and can serve as vehicles for drug delivery. We have previously identified thioaptamers that bind a subset of MDSCs with high a_nity and specificity. In the current study, we applied one of the thioaptamers as a probe to track myeloid cell distribution in the bone, liver, spleen and tumor in multiple murine models of breast cancer including the 4T1 syngeneic model and MDA-MB-231 and SUM159 xenograft models. Information generated from this study will facilitate further understanding of tumor growth and metastasis, and predict biodistribution patterns of cell-mediated drug delivery.
KW - 1R01CA222959 and U54CA210181)
KW - And METAvivor
KW - Biodistribution
KW - Breast cancer
KW - Golfers Against Cancer
KW - Myeloid-derived suppressor cell
KW - Thioaptamer This study was partially supported by grants from the National Cancer Institute (1R01CA193880
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U2 - 10.3390/genes10040297
DO - 10.3390/genes10040297
M3 - Article
AN - SCOPUS:85068385063
SN - 2073-4425
VL - 10
JO - Genes
JF - Genes
IS - 4
M1 - 297
ER -