TY - JOUR
T1 - Trauma exposure and sleep
T2 - Using a rodent model to understand sleep function in PTSD
AU - Vanderheyden, William M.
AU - Poe, Gina R.
AU - Liberzon, Israel
PY - 2014/5
Y1 - 2014/5
N2 - Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep-wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC activity may be playing a key role in symptom formation in PTSD via sleep dysregulation and suppression of hippocampal bidirectional plasticity.
AB - Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep-wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC activity may be playing a key role in symptom formation in PTSD via sleep dysregulation and suppression of hippocampal bidirectional plasticity.
KW - Locus coeruleus
KW - PTSD
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=84900326653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900326653&partnerID=8YFLogxK
U2 - 10.1007/s00221-014-3890-4
DO - 10.1007/s00221-014-3890-4
M3 - Review article
C2 - 24623353
AN - SCOPUS:84900326653
SN - 0014-4819
VL - 232
SP - 1575
EP - 1584
JO - Experimental Brain Research
JF - Experimental Brain Research
IS - 5
ER -