TY - JOUR
T1 - Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch
T2 - consensus guidelines from the International Ileal Pouch Consortium
AU - Shen, Bo
AU - Kochhar, Gursimran S.
AU - Rubin, David T.
AU - Kane, Sunanda V.
AU - Navaneethan, Udayakumar
AU - Bernstein, Charles N.
AU - Cross, Raymond K.
AU - Sugita, Akira
AU - Schairer, Jason
AU - Kiran, Ravi P.
AU - Fleshner, Philip
AU - McCormick, James T.
AU - D'Hoore, André
AU - Shah, Samir A.
AU - Farraye, Francis A.
AU - Kariv, Revital
AU - Liu, Xiuli
AU - Rosh, Joel
AU - Chang, Shannon
AU - Scherl, Ellen
AU - Schwartz, David A.
AU - Kotze, Paulo Gustavo
AU - Bruining, David H.
AU - Philpott, Jessica
AU - Abraham, Bincy
AU - Segal, Jonathan
AU - Sedano, Rocio
AU - Kayal, Maia
AU - Bentley-Hibbert, Stuart
AU - Tarabar, Dino
AU - El-Hachem, Sandra
AU - Sehgal, Priya
AU - Picoraro, Joseph A.
AU - Vermeire, Séverine
AU - Sandborn, William J.
AU - Silverberg, Mark S.
AU - Pardi, Darrell S.
N1 - Funding Information:
WJS is funded in part by the NIDDK-funded San Diego Digestive Diseases Research Center (P30 DK120515). JAP is supported by the Dan and Jill Wallen Family Fund. BS holds the Edelman-Jarislowski Professorship in Surgical Sciences, and would also like to thank David Quint and Sheila Quint for their generous support for the Columbia University Ileal Pouch Center. The Consensus group is grateful to Allegheny General Hospital for providing Continuing Medical Education credits for the Delphi meeting.
Funding Information:
WJS is funded in part by the NIDDK-funded San Diego Digestive Diseases Research Center (P30 DK120515). JAP is supported by the Dan and Jill Wallen Family Fund. BS holds the Edelman-Jarislowski Professorship in Surgical Sciences, and would also like to thank David Quint and Sheila Quint for their generous support for the Columbia University Ileal Pouch Center. The Consensus group is grateful to Allegheny General Hospital for providing Continuing Medical Education credits for the Delphi meeting.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/1
Y1 - 2022/1
N2 - Pouchitis, Crohn's disease of the pouch, cuffitis, polyps, and extraintestinal manifestations of inflammatory bowel disease are common inflammatory disorders of the ileal pouch. Acute pouchitis is treated with oral antibiotics and chronic pouchitis often requires anti-inflammatory therapy, including the use of biologics. Aetiological factors for secondary pouchitis should be evaluated and managed accordingly. Crohn's disease of the pouch is usually treated with biologics and its stricturing and fistulising complications can be treated with endoscopy or surgery. The underlying cause of cuffitis determines treatment strategies. Endoscopic polypectomy is recommended for large, symptomatic inflammatory polyps and polyps in the cuff. The management principles of extraintestinal manifestations of inflammatory bowel disease in patients with pouches are similar to those in patients without pouches.
AB - Pouchitis, Crohn's disease of the pouch, cuffitis, polyps, and extraintestinal manifestations of inflammatory bowel disease are common inflammatory disorders of the ileal pouch. Acute pouchitis is treated with oral antibiotics and chronic pouchitis often requires anti-inflammatory therapy, including the use of biologics. Aetiological factors for secondary pouchitis should be evaluated and managed accordingly. Crohn's disease of the pouch is usually treated with biologics and its stricturing and fistulising complications can be treated with endoscopy or surgery. The underlying cause of cuffitis determines treatment strategies. Endoscopic polypectomy is recommended for large, symptomatic inflammatory polyps and polyps in the cuff. The management principles of extraintestinal manifestations of inflammatory bowel disease in patients with pouches are similar to those in patients without pouches.
KW - Acute Disease
KW - Anti-Bacterial Agents/therapeutic use
KW - Anti-Inflammatory Agents/therapeutic use
KW - Biological Products/therapeutic use
KW - Chronic Disease
KW - Colonic Pouches/adverse effects
KW - Consensus
KW - Constriction, Pathologic/etiology
KW - Crohn Disease/complications
KW - Cutaneous Fistula/therapy
KW - Gastrointestinal Agents/therapeutic use
KW - Humans
KW - Intestinal Fistula/therapy
KW - Intestinal Polyps/surgery
KW - Maintenance Chemotherapy
KW - Pouchitis/drug therapy
KW - Recurrence
KW - Risk Factors
KW - Secondary Prevention/methods
KW - Tumor Necrosis Factor-alpha/antagonists & inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85121007487&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121007487&partnerID=8YFLogxK
U2 - 10.1016/S2468-1253(21)00214-4
DO - 10.1016/S2468-1253(21)00214-4
M3 - Review article
C2 - 34774224
AN - SCOPUS:85121007487
SN - 2468-1253
VL - 7
SP - 69
EP - 95
JO - The Lancet Gastroenterology and Hepatology
JF - The Lancet Gastroenterology and Hepatology
IS - 1
ER -