Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US

Jamalena Thompson; Collins Onyenaka; Emmanuella Oduguwa; Deepa Dongarwar; Sumaya Gendra; Vidella Coker; Seun Kutse; Mayra Blanco; Onyinye Nwangwu; Charlee King; Elza Enamorado; Oluwatoyin Bakare; Veronica B. Ajewole; Kiara K. Spooner; Jason L. Salemi; Muktar H. Aliyu; Hamisu M. Salihu; Omonike A. Olaleye

doi:10.1007/s40615-020-00826-3

Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US

Jamalena Thompson, Collins Onyenaka, Emmanuella Oduguwa, Deepa Dongarwar, Sumaya Gendra, Vidella Coker, Seun Kutse, Mayra Blanco, Onyinye Nwangwu, Charlee King, Elza Enamorado, Oluwatoyin Bakare, Veronica B. Ajewole, Kiara K. Spooner, Jason L. Salemi, Muktar H. Aliyu, Hamisu M. Salihu, Omonike A. Olaleye

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1 Scopus citations

Abstract

Background: Preeclampsia and HIV account for a significant proportion of the global burden of disease and pose severe maternal–fetal risks. There is a dearth of literature regarding racial/ethnic disparities in preeclampsia associated with HIV/AIDS in the US. Methods: We retrospectively analyzed data from the National Inpatient Sample (NIS) database from 2002 to 2015 on a cohort of hospitalized pregnant women with or without preeclampsia and HIV. Joinpoint regression models were used to identify trends in the rates of preeclampsia among pregnant women living with or without HIV, stratified by race/ethnicity over the study period. We also assessed the association between preeclampsia and various socio-demographic factors. Results: We analyzed over 60 million pregnancy-related hospitalizations, of which 3665 had diagnoses of preeclampsia and HIV, corresponding to a rate of 0.61 per 10,000. There was an increasing trend in the diagnosis of preeclampsia among hospitalized, pregnant women without HIV across each racial/ethnic category. The highest prevalence of preeclampsia was among non-Hispanic (NH) Blacks, regardless of HIV status. Conclusion: The increase in rates of pre-eclampsia between 2002 and 2015 was mostly noted among pregnant women without HIV. Regardless of HIV status, NH-Blacks experienced the highest discharge prevalence of preeclampsia.

Original language	English (US)
Pages (from-to)	670-677
Number of pages	8
Journal	Journal of Racial and Ethnic Health Disparities
Volume	8
Issue number	3
DOIs	https://doi.org/10.1007/s40615-020-00826-3
State	Published - Jun 2021

Keywords

HIV
Maternal-fetal health
Preeclampsia
Pregnancy
Racial disparities

ASJC Scopus subject areas

Health(social science)
Anthropology
Sociology and Political Science
Health Policy
Public Health, Environmental and Occupational Health

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10.1007/s40615-020-00826-3

Cite this

Thompson, J., Onyenaka, C., Oduguwa, E., Dongarwar, D., Gendra, S., Coker, V., Kutse, S., Blanco, M., Nwangwu, O., King, C., Enamorado, E., Bakare, O., Ajewole, V. B., Spooner, K. K., Salemi, J. L., Aliyu, M. H., Salihu, H. M., & Olaleye, O. A. (2021). Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US. Journal of Racial and Ethnic Health Disparities, 8(3), 670-677. https://doi.org/10.1007/s40615-020-00826-3

Thompson, J, Onyenaka, C, Oduguwa, E, Dongarwar, D, Gendra, S, Coker, V, Kutse, S, Blanco, M, Nwangwu, O, King, C, Enamorado, E, Bakare, O, Ajewole, VB, Spooner, KK, Salemi, JL, Aliyu, MH, Salihu, HM & Olaleye, OA 2021, 'Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US', Journal of Racial and Ethnic Health Disparities, vol. 8, no. 3, pp. 670-677. https://doi.org/10.1007/s40615-020-00826-3

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title = "Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US",

abstract = "Background: Preeclampsia and HIV account for a significant proportion of the global burden of disease and pose severe maternal–fetal risks. There is a dearth of literature regarding racial/ethnic disparities in preeclampsia associated with HIV/AIDS in the US. Methods: We retrospectively analyzed data from the National Inpatient Sample (NIS) database from 2002 to 2015 on a cohort of hospitalized pregnant women with or without preeclampsia and HIV. Joinpoint regression models were used to identify trends in the rates of preeclampsia among pregnant women living with or without HIV, stratified by race/ethnicity over the study period. We also assessed the association between preeclampsia and various socio-demographic factors. Results: We analyzed over 60 million pregnancy-related hospitalizations, of which 3665 had diagnoses of preeclampsia and HIV, corresponding to a rate of 0.61 per 10,000. There was an increasing trend in the diagnosis of preeclampsia among hospitalized, pregnant women without HIV across each racial/ethnic category. The highest prevalence of preeclampsia was among non-Hispanic (NH) Blacks, regardless of HIV status. Conclusion: The increase in rates of pre-eclampsia between 2002 and 2015 was mostly noted among pregnant women without HIV. Regardless of HIV status, NH-Blacks experienced the highest discharge prevalence of preeclampsia.",

keywords = "HIV, Maternal-fetal health, Preeclampsia, Pregnancy, Racial disparities",

author = "Jamalena Thompson and Collins Onyenaka and Emmanuella Oduguwa and Deepa Dongarwar and Sumaya Gendra and Vidella Coker and Seun Kutse and Mayra Blanco and Onyinye Nwangwu and Charlee King and Elza Enamorado and Oluwatoyin Bakare and Ajewole, {Veronica B.} and Spooner, {Kiara K.} and Salemi, {Jason L.} and Aliyu, {Muktar H.} and Salihu, {Hamisu M.} and Olaleye, {Omonike A.}",

note = "Funding Information: Research funding support was provided by the US Department of Health and Human Services, Health Resources and Services Administration for the Maternal and Child Health Pipeline Training Program: TSU-BCM Maternal and Child Health Student Training for Academic Readiness and Success (MCH STARS) Undergraduate Fellowship Program, Grant No: T16MC29831. Acknowledgments Publisher Copyright: {\textcopyright} 2020, W. Montague Cobb-NMA Health Institute. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jun,

doi = "10.1007/s40615-020-00826-3",

language = "English (US)",

volume = "8",

pages = "670--677",

journal = "Journal of Racial and Ethnic Health Disparities",

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T1 - Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US

AU - Thompson, Jamalena

AU - Onyenaka, Collins

AU - Oduguwa, Emmanuella

AU - Dongarwar, Deepa

AU - Gendra, Sumaya

AU - Coker, Vidella

AU - Kutse, Seun

AU - Blanco, Mayra

AU - Nwangwu, Onyinye

AU - King, Charlee

AU - Enamorado, Elza

AU - Bakare, Oluwatoyin

AU - Ajewole, Veronica B.

AU - Spooner, Kiara K.

AU - Salemi, Jason L.

AU - Aliyu, Muktar H.

AU - Salihu, Hamisu M.

AU - Olaleye, Omonike A.

N1 - Funding Information: Research funding support was provided by the US Department of Health and Human Services, Health Resources and Services Administration for the Maternal and Child Health Pipeline Training Program: TSU-BCM Maternal and Child Health Student Training for Academic Readiness and Success (MCH STARS) Undergraduate Fellowship Program, Grant No: T16MC29831. Acknowledgments Publisher Copyright: © 2020, W. Montague Cobb-NMA Health Institute. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - Background: Preeclampsia and HIV account for a significant proportion of the global burden of disease and pose severe maternal–fetal risks. There is a dearth of literature regarding racial/ethnic disparities in preeclampsia associated with HIV/AIDS in the US. Methods: We retrospectively analyzed data from the National Inpatient Sample (NIS) database from 2002 to 2015 on a cohort of hospitalized pregnant women with or without preeclampsia and HIV. Joinpoint regression models were used to identify trends in the rates of preeclampsia among pregnant women living with or without HIV, stratified by race/ethnicity over the study period. We also assessed the association between preeclampsia and various socio-demographic factors. Results: We analyzed over 60 million pregnancy-related hospitalizations, of which 3665 had diagnoses of preeclampsia and HIV, corresponding to a rate of 0.61 per 10,000. There was an increasing trend in the diagnosis of preeclampsia among hospitalized, pregnant women without HIV across each racial/ethnic category. The highest prevalence of preeclampsia was among non-Hispanic (NH) Blacks, regardless of HIV status. Conclusion: The increase in rates of pre-eclampsia between 2002 and 2015 was mostly noted among pregnant women without HIV. Regardless of HIV status, NH-Blacks experienced the highest discharge prevalence of preeclampsia.

AB - Background: Preeclampsia and HIV account for a significant proportion of the global burden of disease and pose severe maternal–fetal risks. There is a dearth of literature regarding racial/ethnic disparities in preeclampsia associated with HIV/AIDS in the US. Methods: We retrospectively analyzed data from the National Inpatient Sample (NIS) database from 2002 to 2015 on a cohort of hospitalized pregnant women with or without preeclampsia and HIV. Joinpoint regression models were used to identify trends in the rates of preeclampsia among pregnant women living with or without HIV, stratified by race/ethnicity over the study period. We also assessed the association between preeclampsia and various socio-demographic factors. Results: We analyzed over 60 million pregnancy-related hospitalizations, of which 3665 had diagnoses of preeclampsia and HIV, corresponding to a rate of 0.61 per 10,000. There was an increasing trend in the diagnosis of preeclampsia among hospitalized, pregnant women without HIV across each racial/ethnic category. The highest prevalence of preeclampsia was among non-Hispanic (NH) Blacks, regardless of HIV status. Conclusion: The increase in rates of pre-eclampsia between 2002 and 2015 was mostly noted among pregnant women without HIV. Regardless of HIV status, NH-Blacks experienced the highest discharge prevalence of preeclampsia.

KW - HIV

KW - Maternal-fetal health

KW - Preeclampsia

KW - Pregnancy

KW - Racial disparities

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Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US

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