Abstract
The importance of T-cell-mediated antitumor immunity has been demonstrated in both animal models and human cancer immunotherapy. The identification of tumor antigens from various types of cancer has generated a resurgence of interest in immunotherapy for cancer and provides the stage to develop therapeutic cancer vaccines. However, recent clinical studies indicate that immunity generated by peptide or DC/peptide vaccines is not sufficient to eradicate cancer. One of the major factors for the weak and transient immune response is the presence of immune suppression in tumor microenvironment. Regulatory T cells and myeloid-derived suppressor cells are major cell types that are responsible for immune suppression. Novel strategies have been developed for enhancing T-cell responses against cancer by overcoming immune suppression. Combination of antigen-specific vaccines to stimulate effector T cells with anti-immune suppression provides opportunities for developing effective cancer vaccines.
Original language | English (US) |
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Title of host publication | Innate Immune Regulation and Cancer Immunotherapy |
Publisher | Springer New York |
Pages | 371-390 |
Number of pages | 20 |
ISBN (Electronic) | 9781441999146 |
ISBN (Print) | 9781441999139 |
DOIs | |
State | Published - Jan 1 2012 |
ASJC Scopus subject areas
- Medicine(all)