TY - JOUR
T1 - Tympanic Mucosa After Tubal Obstruction
T2 - An Ultrastructural Observation
AU - Lim, David
AU - Hussl, Burkhard
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1970/6
Y1 - 1970/6
N2 - An attempt was made to create serous effusions in the middle ear cavity of the guinea pig by obstructing the eustachian tube. Histologic sections, however, indicated that only an incomplete occlusion of the tube was present. Among the 11 animals used, six developed a serous or seromucous effusion. The predominant findings were: (1) the loss of ciliated cells in the early stages (eight days) and (2) an increase in the number of dark-granulated cells. The thickening of the submucosal layer was due to an increased cellularity with the deposition of dense cottony spheres in the matrix. These densities are similar to calcium crystals found in early ossification centers. There was also an increased cellular infiltration consisting primarily of polymorphs, but also including round-cell types and macrophages. No evidence of bacterial invasion was found.
AB - An attempt was made to create serous effusions in the middle ear cavity of the guinea pig by obstructing the eustachian tube. Histologic sections, however, indicated that only an incomplete occlusion of the tube was present. Among the 11 animals used, six developed a serous or seromucous effusion. The predominant findings were: (1) the loss of ciliated cells in the early stages (eight days) and (2) an increase in the number of dark-granulated cells. The thickening of the submucosal layer was due to an increased cellularity with the deposition of dense cottony spheres in the matrix. These densities are similar to calcium crystals found in early ossification centers. There was also an increased cellular infiltration consisting primarily of polymorphs, but also including round-cell types and macrophages. No evidence of bacterial invasion was found.
UR - http://www.scopus.com/inward/record.url?scp=0014805023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014805023&partnerID=8YFLogxK
U2 - 10.1001/archotol.1970.00770040815017
DO - 10.1001/archotol.1970.00770040815017
M3 - Article
C2 - 5443362
AN - SCOPUS:0014805023
SN - 0276-0673
VL - 91
SP - 585
EP - 593
JO - Archives of Otolaryngology
JF - Archives of Otolaryngology
IS - 6
ER -