Ultrastructural localization of aluminium in liver of aluminium maltol‐treated rabbits by laser microprobe mass analysis

D. Vandeputte; R. E. Van Grieken; W. A. Jacob; J. Savory; R. L. Bertholf; M. R. Wills

doi:10.1002/bms.1200180815

Ultrastructural localization of aluminium in liver of aluminium maltol‐treated rabbits by laser microprobe mass analysis

D. Vandeputte, R. E. Van Grieken, W. A. Jacob, J. Savory, R. L. Bertholf, M. R. Wills

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

By means of laser microprobe mass analysis (LAMMA), we have studied the ultrastructural localization of aluminium in livers of aluminium maltol‐treated rabbits. This animal model was developed to study long‐term aluminium toxicity using systemic (intravenous) administration of aluminium. We could only detect aluminium in electron‐dense inclusion bodies found in large, sometimes multinucleated cells. These results prove that the actual observation of aluminium deposits in liver with LAMMA gives more information than bulk analysis and can be very useful to explore mechanisms of toxicity.

Original language	English (US)
Pages (from-to)	598-602
Number of pages	5
Journal	Biomedical & environmental mass spectrometry
Volume	18
Issue number	8
DOIs	https://doi.org/10.1002/bms.1200180815
State	Published - Aug 1989

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pollution

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title = "Ultrastructural localization of aluminium in liver of aluminium maltol‐treated rabbits by laser microprobe mass analysis",

abstract = "By means of laser microprobe mass analysis (LAMMA), we have studied the ultrastructural localization of aluminium in livers of aluminium maltol‐treated rabbits. This animal model was developed to study long‐term aluminium toxicity using systemic (intravenous) administration of aluminium. We could only detect aluminium in electron‐dense inclusion bodies found in large, sometimes multinucleated cells. These results prove that the actual observation of aluminium deposits in liver with LAMMA gives more information than bulk analysis and can be very useful to explore mechanisms of toxicity.",

author = "D. Vandeputte and {Van Grieken}, {R. E.} and Jacob, {W. A.} and J. Savory and Bertholf, {R. L.} and Wills, {M. R.}",

year = "1989",

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AU - Van Grieken, R. E.

AU - Jacob, W. A.

AU - Savory, J.

AU - Bertholf, R. L.

AU - Wills, M. R.

PY - 1989/8

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AB - By means of laser microprobe mass analysis (LAMMA), we have studied the ultrastructural localization of aluminium in livers of aluminium maltol‐treated rabbits. This animal model was developed to study long‐term aluminium toxicity using systemic (intravenous) administration of aluminium. We could only detect aluminium in electron‐dense inclusion bodies found in large, sometimes multinucleated cells. These results prove that the actual observation of aluminium deposits in liver with LAMMA gives more information than bulk analysis and can be very useful to explore mechanisms of toxicity.

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Ultrastructural localization of aluminium in liver of aluminium maltol‐treated rabbits by laser microprobe mass analysis

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