@article{6ebb2404de0643e49adf9a39ea48ea1f,
title = "Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation",
abstract = "Ultraviolet irradiation (UV) of cadmium-sensitive S49 mouse cells induces a large increase in cadmiumresistant variants. About 30%-40% of these variants make metallothionein (MT)-I mRNA while S49 cells do not. S49 cells contain two copies of the MT-I gene; both alleles are heavily methylated but can be conveniently distinguished by the methylation status of a single Hpa II site. In lines expressing MT-I, one allele becomes completely demethylated at all methylation-sensitive restriction sites examined over at least a 2.5 kb region spanning the MT-I gene. Activation of a quiescent gene by UV has implications for understanding the initiation of carcinogenesis.",
author = "Lieberman, {Michael W.} and Beach, {Larry R.} and Palmiter, {Richard D.}",
note = "Funding Information: We thank our colleagues at the University of Washington (Seattle) and Washington University (St . Louis) for their helpful suggestions . We are especially grateful to Diane M. Durnam and Kelly E . Mayo for their many thoughtful comments . We thank Andrew Lassar and Robert Roeder for a gift of pMGS-1 . Part of this work was performed while M . W . L. was a visiting scholar in the Department of Biochemistry, University of Washington . This work was supported in part by National Institutes of Health grants to M . W . L . and to R . D. P. and by support to the Department of Pathology of Washington University Medical School provided by Brown and Williamson Tobacco Corporation, Phillip Morris, Inc ., R. J . Reynolds Tobacco Company, and the United States Tobacco Company . Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1983",
month = nov,
doi = "10.1016/0092-8674(83)90223-4",
language = "English (US)",
volume = "35",
pages = "207--214",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}