Unraveling multilayered extracellular vesicles: Speculation on cause

Kelly Broad; Sierra A. Walker; Irina Davidovich; Kenneth Witwer; Yeshayahu Talmon; Joy Wolfram

doi:10.1002/jev2.12309

Unraveling multilayered extracellular vesicles: Speculation on cause

Kelly Broad, Sierra A. Walker, Irina Davidovich, Kenneth Witwer, Yeshayahu Talmon, Joy Wolfram

Research output: Contribution to journal › Letter › peer-review

16 Scopus citations

Abstract

Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.

Original language	English (US)
Article number	e12309
Pages (from-to)	e12309
Journal	Journal of Extracellular Vesicles
Volume	12
Issue number	2
DOIs	https://doi.org/10.1002/jev2.12309
State	Published - Feb 2023

Keywords

ectosome
exosome
microvesicle
multilamellar
unilamellar
Biological Transport
Cell Communication
Extracellular Vesicles/metabolism

ASJC Scopus subject areas

Cell Biology
Histology

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10.1002/jev2.12309

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title = "Unraveling multilayered extracellular vesicles: Speculation on cause",

abstract = "Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.",

keywords = "ectosome, exosome, microvesicle, multilamellar, unilamellar, Biological Transport, Cell Communication, Extracellular Vesicles/metabolism",

author = "Kelly Broad and Walker, {Sierra A.} and Irina Davidovich and Kenneth Witwer and Yeshayahu Talmon and Joy Wolfram",

note = "Funding Information: Partial funding was provided by The University of Queensland, Australia (JW) and the Israel Science Foundation, Israel under award 2302/20 (YT). The cryo‐TEM work was performed at the Technion Center for Electron Microscopy of Soft Matter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the organizations and funding agencies. Publisher Copyright: {\textcopyright} 2023 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.",

year = "2023",

month = feb,

doi = "10.1002/jev2.12309",

language = "English (US)",

volume = "12",

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TY - JOUR

T1 - Unraveling multilayered extracellular vesicles

T2 - Speculation on cause

AU - Broad, Kelly

AU - Walker, Sierra A.

AU - Davidovich, Irina

AU - Witwer, Kenneth

AU - Talmon, Yeshayahu

AU - Wolfram, Joy

N1 - Funding Information: Partial funding was provided by The University of Queensland, Australia (JW) and the Israel Science Foundation, Israel under award 2302/20 (YT). The cryo‐TEM work was performed at the Technion Center for Electron Microscopy of Soft Matter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the organizations and funding agencies. Publisher Copyright: © 2023 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

PY - 2023/2

Y1 - 2023/2

N2 - Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.

AB - Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.

KW - ectosome

KW - exosome

KW - microvesicle

KW - multilamellar

KW - unilamellar

KW - Biological Transport

KW - Cell Communication

KW - Extracellular Vesicles/metabolism

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U2 - 10.1002/jev2.12309

DO - 10.1002/jev2.12309

M3 - Letter

C2 - 36732941

AN - SCOPUS:85147319126

SN - 2001-3078

VL - 12

SP - e12309

JO - Journal of Extracellular Vesicles

JF - Journal of Extracellular Vesicles

IS - 2

M1 - e12309

ER -

Unraveling multilayered extracellular vesicles: Speculation on cause

Abstract

Keywords

ASJC Scopus subject areas

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