Update on estrogen signaling

Zhang Weihua; Sandra Andersson; Guojun Cheng; Evan R. Simpson; Margaret Warner; Jan Åke Gustafsson

doi:10.1016/S0014-5793(03)00436-8

Update on estrogen signaling

Zhang Weihua, Sandra Andersson, Guojun Cheng, Evan R. Simpson, Margaret Warner, Jan Åke Gustafsson

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

Abstract

Our understanding of estrogen signaling has undergone a true paradigm shift over recent years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor β (ERβ). In many contexts ERβ appears to antagonize the actions of ERα (yin/yang relationship) although there also exist genes that are specifically regulated by one of the two receptors. Studies of ERβ knockout mice have shown that ERβ exerts important functions in the ovary, central nervous system, mammary gland, prostate gland, hematopoiesis, immune system, vessels and bone. The use of ERβ-specific ligands against certain forms of cancer represents one of the many pharmaceutical possibilities that have been created thanks to the discovery of ERβ.

Original language	English (US)
Pages (from-to)	17-24
Number of pages	8
Journal	FEBS Letters
Volume	546
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(03)00436-8
State	Published - Jul 3 2003

Keywords

Breast cancer
Central nervous system
Estrogen
Estrogen receptor
Prostate

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/S0014-5793(03)00436-8

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abstract = "Our understanding of estrogen signaling has undergone a true paradigm shift over recent years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor β (ERβ). In many contexts ERβ appears to antagonize the actions of ERα (yin/yang relationship) although there also exist genes that are specifically regulated by one of the two receptors. Studies of ERβ knockout mice have shown that ERβ exerts important functions in the ovary, central nervous system, mammary gland, prostate gland, hematopoiesis, immune system, vessels and bone. The use of ERβ-specific ligands against certain forms of cancer represents one of the many pharmaceutical possibilities that have been created thanks to the discovery of ERβ.",

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AU - Weihua, Zhang

AU - Andersson, Sandra

AU - Cheng, Guojun

AU - Simpson, Evan R.

AU - Warner, Margaret

AU - Gustafsson, Jan Åke

N1 - Funding Information: These studies were supported by the Swedish Cancer Fund and KaroBio AB.

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AB - Our understanding of estrogen signaling has undergone a true paradigm shift over recent years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor β (ERβ). In many contexts ERβ appears to antagonize the actions of ERα (yin/yang relationship) although there also exist genes that are specifically regulated by one of the two receptors. Studies of ERβ knockout mice have shown that ERβ exerts important functions in the ovary, central nervous system, mammary gland, prostate gland, hematopoiesis, immune system, vessels and bone. The use of ERβ-specific ligands against certain forms of cancer represents one of the many pharmaceutical possibilities that have been created thanks to the discovery of ERβ.

KW - Breast cancer

KW - Central nervous system

KW - Estrogen

KW - Estrogen receptor

KW - Prostate

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Update on estrogen signaling

Abstract

Keywords

ASJC Scopus subject areas

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