TY - JOUR
T1 - Update
T2 - The Miller Fisher variants of Guillain-Barré syndrome
AU - Al Othman, Bayan
AU - Raabe, Jared
AU - Kini, Ashwini
AU - Lee, Andrew G.
N1 - Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Purpose of reviewThis article will update and review the Miller Fisher variants (MFV) of Guillain-Barré syndrome (GBS) including the clinical presentation, diagnostic testing, and treatment.Recent findingsAlthough the diagnosis of GBS and MFV can be made on clinical grounds, cerebrospinal fluid (CSF) analysis, nerve conduction studies, imaging (e.g. ultrasound and MRI), and serologic testing can help to confirm the diagnosis. Some patients may need immunotherapy with either intravenous immunoglobulin (IVIg) or plasma exchange, and recent studies suggest that complement inhibition combined with IVIg could be of benefit, but further studies are needed to prove efficacy.SummaryGBS is characterized by an acute, ascending polyneuropathy, ataxia, areflexia, and CSF albuminocytologic dissociation. The MFV of GBS is associated with ophthalmoplegia. Clinicians should have high index of suspicion for MFV of GBS in patients with acute ophthalmoplegia in order to establish the diagnosis, perform appropriate evaluation, and start treatment.SDC video link:http://links.lww.com/COOP/A32.
AB - Purpose of reviewThis article will update and review the Miller Fisher variants (MFV) of Guillain-Barré syndrome (GBS) including the clinical presentation, diagnostic testing, and treatment.Recent findingsAlthough the diagnosis of GBS and MFV can be made on clinical grounds, cerebrospinal fluid (CSF) analysis, nerve conduction studies, imaging (e.g. ultrasound and MRI), and serologic testing can help to confirm the diagnosis. Some patients may need immunotherapy with either intravenous immunoglobulin (IVIg) or plasma exchange, and recent studies suggest that complement inhibition combined with IVIg could be of benefit, but further studies are needed to prove efficacy.SummaryGBS is characterized by an acute, ascending polyneuropathy, ataxia, areflexia, and CSF albuminocytologic dissociation. The MFV of GBS is associated with ophthalmoplegia. Clinicians should have high index of suspicion for MFV of GBS in patients with acute ophthalmoplegia in order to establish the diagnosis, perform appropriate evaluation, and start treatment.SDC video link:http://links.lww.com/COOP/A32.
KW - Guillain-Barré
KW - Miller Fisher
KW - anti-GQ1b
KW - autoimmune
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UR - http://www.scopus.com/inward/citedby.url?scp=85072576322&partnerID=8YFLogxK
U2 - 10.1097/ICU.0000000000000611
DO - 10.1097/ICU.0000000000000611
M3 - Article
C2 - 31567467
AN - SCOPUS:85072576322
SN - 1040-8738
VL - 30
SP - 462
EP - 466
JO - Current Opinion in Ophthalmology
JF - Current Opinion in Ophthalmology
IS - 6
ER -