TY - JOUR
T1 - Use of T2MR in invasive candidiasis with and without candidemia
AU - Zacharioudakis, Ioannis M.
AU - Zervou, Fainareti N.
AU - Mylonakis, Eleftherios
N1 - Funding Information:
E Mylonakis has received grant support from Boehringer Ingelheim, T2 Biosystems and Astellas. The other authors have no conflict of interest to declare. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Publisher Copyright:
© 2018 2018 Future Medicine Ltd.
PY - 2018/8
Y1 - 2018/8
N2 - The mortality associated with invasive candidiasis remains unacceptably high. The T2 magnetic resonance (T2MR) assay is a novel US FDA-Approved molecular diagnostic assay for the diagnosis of candidemia that can rapidly detect the five most commonly isolated Candida spp. In clinical trials, T2MR has exhibited good clinical sensitivity and specificity. Potential benefits from the adoption of T2MR technology in the diagnostic and therapeutic algorithms for invasive candidiasis can arise from timely diagnosis of disease, increased case detection, tailored therapy and decrease in empiric antifungal treatment. As everyday clinical experience with the assay is evolving, we discuss the utility of T2MR in invasive candidiasis with and without candidemia based on the currently available evidence regarding its performance.
AB - The mortality associated with invasive candidiasis remains unacceptably high. The T2 magnetic resonance (T2MR) assay is a novel US FDA-Approved molecular diagnostic assay for the diagnosis of candidemia that can rapidly detect the five most commonly isolated Candida spp. In clinical trials, T2MR has exhibited good clinical sensitivity and specificity. Potential benefits from the adoption of T2MR technology in the diagnostic and therapeutic algorithms for invasive candidiasis can arise from timely diagnosis of disease, increased case detection, tailored therapy and decrease in empiric antifungal treatment. As everyday clinical experience with the assay is evolving, we discuss the utility of T2MR in invasive candidiasis with and without candidemia based on the currently available evidence regarding its performance.
KW - T2Candida
KW - T2MR
KW - abdominal candidiasis
KW - candidemia
KW - chronic disseminated candidiasis
KW - invasive candidiasis
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U2 - 10.2217/fmb-2018-0079
DO - 10.2217/fmb-2018-0079
M3 - Review article
C2 - 29792512
AN - SCOPUS:85053277118
SN - 1746-0913
VL - 13
SP - 1165
EP - 1173
JO - Future Microbiology
JF - Future Microbiology
IS - 10
ER -